Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox
文献类型：期刊论文
| 作者 | Deng, Zhen-Tao1,2,4; Geng, Chang-An1,2 ; Yang, Tong-Hua1,2; Xiang, Chun-Lei3; Chen, Ji-Jun1,2,4
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2019 |
| 卷号 | 132页码:60-67 |
| 关键词 | Chelonopsis praecox chepraecoxins A-G ent-kaurane diterpenoids alpha-glucosidase |
| ISSN号 | 0367-326X |
| 英文摘要 | Our random bioassay revealed that the CHCl3 part of Chelonopsis praecox (Lamiaceae) showed significant activity against alpha-glucosidase with the inhibitory rate of 99.6 +/- 0.4 % (330 mu g/mL). Bioassay-guided isolation yielded seven new ent-kaurane diterpenoids, chepraecoxins A-G (1-7), and three known ones (8-10), driven by LC-MS analyses. The structures of chepraecoxins A-G (1-7) were elucidated by X-ray crystallographic and extensive spectroscopic analyses. Compounds 1, 6, and 10 showed obvious alpha-glucosidase inhibitory effects with IC50 values of 305.0, 361.0 and 174.5 mu M, respectively. Enzyme kinetics study suggested that compound 1 inhibited the alpha-glucosidase by a noncompetitive type mechanism (K-i = 354.4 mu M). |
| 资助项目 | Youth Innovation Promotion Association CAS[2013252] ; Southeast Asia Biodiversity Research Institute, CAS[2017CASSEABRIQG003] ; Program of Yunling Scholarship ; CAS Light of West China Program ; CAS Hundred Talents Program |
| 语种 | 英语 |
| 资助机构 | Youth Innovation Promotion Association CAS ; Southeast Asia Biodiversity Research Institute, CAS ; Program of Yunling Scholarship ; CAS Light of West China Program ; CAS Hundred Talents Program |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64397]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室 |
| 通讯作者 | Chen, Ji-Jun |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Key Lab Plant Divers & Biogeog East Asia, Kunming 650201, Yunnan, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,et al. Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox[J]. FITOTERAPIA,2019,132:60-67. |
| APA | Deng, Zhen-Tao,Geng, Chang-An,Yang, Tong-Hua,Xiang, Chun-Lei,&Chen, Ji-Jun.(2019).Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox.FITOTERAPIA,132,60-67. |
| MLA | Deng, Zhen-Tao,et al."Chepraecoxins A-G, ent-Kaurane Diterpenoids with alpha-Glucosidase Inhibitory Activities from Chelonopsis praecox".FITOTERAPIA 132(2019):60-67. |
入库方式： OAI收割
来源：昆明植物研究所
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