In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition
文献类型：期刊论文
| 作者 | Zhang, Ying; Wang, Wei; Xie, Yubing; Yu, Weiting; Teng, Huaining; Liu, Xiudong; Zhang, Xulang; Guo, Xin; Fei, Jian; Ma, Xiaojun |
| 刊名 | human gene therapy
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 18期号:5页码:474-481 |
| 产权排序 | 1;1 |
| 通讯作者 | 马小军 |
| 英文摘要 | microencapsulation of recombinant cells is a novel alternative approach to tumor gene therapy. therapeutic protein delivery can be sustained for systemic treatment of tumors because the recombinant cells are enclosed in microcapsules and the semipermeable membrane of the microcapsules protects the cells from host immune rejection and reduces the need for frequent injection. in this study, we describe a method to systemically inhibit tumor growth by in vivo culture of antiangiogenic endostatin-secreting chinese hamster ovary (cho) cells in microcapsules as small as 200 mu m in diameter. peritoneal administration of encapsulated endostatin-cho cells inhibited melanoma growth to 66.4% and enhanced the survival of treated mice to 80% by 27 days posttreatment. continuous systemic release of endostatin from microcapsules offers an effective therapeutic strategy to eradicate solid tumors. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biotechnology & applied microbiology ; genetics & heredity ; medicine, research & experimental |
| 研究领域[WOS] | biotechnology & applied microbiology ; genetics & heredity ; research & experimental medicine |
| 关键词[WOS] | angiogenesis ; therapy ; cancer ; growth |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000246904400008 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/99055]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ying,Wang, Wei,Xie, Yubing,et al. In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition[J]. human gene therapy,2007,18(5):474-481. |
| APA | Zhang, Ying.,Wang, Wei.,Xie, Yubing.,Yu, Weiting.,Teng, Huaining.,...&Ma, Xiaojun.(2007).In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition.human gene therapy,18(5),474-481. |
| MLA | Zhang, Ying,et al."In vivo culture of encapsulated endostatin-secreting chinese hamster ovary cells for systemic tumor inhibition".human gene therapy 18.5(2007):474-481. |
入库方式： OAI收割
来源：大连化学物理研究所
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