Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.
文献类型：期刊论文
| 作者 | Wei, Xin; Jiang, Li-Ping; Guo, Ying; Khan, Afsar; Liu, Ya-Ping; Yu, Hao-Fei; Wang, Bei; Ding, Cai-Feng; Zhu, Pei-Feng; Chen, Ying-Ying |
| 刊名 | Natural products and bioprospecting
 |
| 出版日期 | 2017 |
| 卷号 | 7期号:5页码:413-419 |
| ISSN号 | 2192-2195 |
| 英文摘要 | Uncaria rhynchophylla is commonly recognized as a traditional treatment for dizziness, cerebrovascular diseases, and nervous disorders in China. Previously, the neuro-protective activities of the alkaloids from U. rhynchophylla were intensively reported. In current work, three new indole alkaloids (1-3), identified as geissoschizic acid (1), geissoschizic acid N 4-oxide (2), and 3beta-sitsirikine N 4-oxide (3), as well as 26 known analogues were isolated from U. rhynchophylla. However, in the neural stem cells (NSCs) proliferation assay for all isolated compounds, geissoschizic acid (1), geissoschizic acid N 4-oxide (2), isocorynoxeine (6), isorhynchophylline (7), (4S)-akuammigine N-oxide (8), and (4S)-rhynchophylline N-oxide (10) showed unexpected inhibitory activities at 10muM. Unlike previous neuro-protective reports, as a warning or caution, our finding showcased a clue for possible NSCs toxicity and the neural lesions risk of U. rhynchophylla, while the structure-activity relationships of the isolated compounds were discussed also. |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64831]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wei, Xin,Jiang, Li-Ping,Guo, Ying,et al. Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.[J]. Natural products and bioprospecting,2017,7(5):413-419. |
| APA | Wei, Xin.,Jiang, Li-Ping.,Guo, Ying.,Khan, Afsar.,Liu, Ya-Ping.,...&Luo, Xiao-Dong.(2017).Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla..Natural products and bioprospecting,7(5),413-419. |
| MLA | Wei, Xin,et al."Indole Alkaloids Inhibiting Neural Stem Cell from Uncaria rhynchophylla.".Natural products and bioprospecting 7.5(2017):413-419. |
入库方式： OAI收割
来源：昆明植物研究所
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