Cytotoxic ergosteroids from the fungus Stereum hirsutum
文献类型：期刊论文
| 作者 | Zhao, Zhen-Zhu1,2,3; Han, Kai-Yue4; Li, Zheng-Hui4; Feng, Tao4; Chen, He-Ping4,5; Liu, Ji-Kai4,5 |
| 刊名 | PHYTOCHEMISTRY LETTERS
 |
| 出版日期 | 2019-04-01 |
| 卷号 | 30页码:143-149 |
| 关键词 | Stereum hirsutum Steroids Semi-synthesis Cytotoxicity |
| ISSN号 | 1874-3900 |
| DOI | 10.1016/j.phytol.2019.02.007 |
| 通讯作者 | Chen, He-Ping(chenhp@mail.scuec.edu.cn) ; Liu, Ji-Kai(jkliu@mail.kib.ac.cn) |
| 英文摘要 | Phytochemical investigation on the fermentation broth of the fungus Stereum hirsutum led to the isolation of ten steroids, including two previously unreported ones, namely steresterones A (1) and B (2). The semi-synthesis products 3a and 3b were prepared by reduction of the known compound 3 with NaBH4. Their structures and absolute configurations were established via 1D & 2D NMR spectroscopic analysis, and TDDFT/ECD calculations as well as single crystal X-ray diffraction analysis. The structure of 3 which harbored a 5 beta-H was confirmed by single crystal X-ray diffraction analysis for the first time. All the compounds reported in this study were evaluated for their cytotoxicity against five human cancer cell lines. Bioassay results revealed that 3, 4, 6-9 displayed significant anti-proliferative effects with IC50 values varying from 2.3 to 34.3 mu M. The structure-activity relationships of 3, 3a, 3b were discussed. |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000461363900028 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/64996]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 通讯作者 | Chen, He-Ping; Liu, Ji-Kai |
| 作者单位 | 1.Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengshou 450046, Peoples R China 2.Henan Univ Chinese Med, Chinese Med Dev Henan Prov, Zhengshou 450046, Peoples R China 3.Henan Univ Chinese Med, Sch Pharm, Zhengsshou 450046, Peoples R China 4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,et al. Cytotoxic ergosteroids from the fungus Stereum hirsutum[J]. PHYTOCHEMISTRY LETTERS,2019,30:143-149. |
| APA | Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,Feng, Tao,Chen, He-Ping,&Liu, Ji-Kai.(2019).Cytotoxic ergosteroids from the fungus Stereum hirsutum.PHYTOCHEMISTRY LETTERS,30,143-149. |
| MLA | Zhao, Zhen-Zhu,et al."Cytotoxic ergosteroids from the fungus Stereum hirsutum".PHYTOCHEMISTRY LETTERS 30(2019):143-149. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。