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T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes

文献类型：期刊论文

作者Ding, Ling1,2,3; Pfoh, Roland4; Ruehl, Stephan4; Qin, Song2; Laatsch, Hartmut1; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2009
卷号72期号:1页码:99-101
ISSN号0163-3864
DOI10.1021/np8006843
文献子类Article
英文摘要Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC(50) of 6.7 mu g/mL.; Two new sesquiterpenes, 15-hydroxy-T-muurolol (3d) and 11,15-dihydroxy-T-muurolol (3e), along with the plant cadinenes T-muurolol (3f) and 3 alpha-hydroxy-T-muurolol (3g), were isolated from the marine-derived Streptomyces sp. M491. Their absolute configuration was established via NMR spectroscopy and X-ray crystallography of 3-oxo-T-muurolol (3a), which was reisolated from this strain. In addition, the absolute configuration of further sesquiterpenes previously reported from this strain was revised. These products were tested for their cytotoxicity against 37 human tumor cell lines using the MTT method. Only 3d was cytotoxic against a range of human tumor cell lines with a mean IC50 of 6.7 mu g/mL.
学科主题Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
URL标识查看原文
语种英语
WOS记录号WOS:000262761700018
公开日期2010-11-18
源URL[http://ir.qdio.ac.cn/handle/337002/1594]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
作者单位1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
4.Univ Gottingen, Dept Inorgan Chem, D-37077 Gottingen, Germany
推荐引用方式
GB/T 7714		 Ding, Ling,Pfoh, Roland,Ruehl, Stephan,et al. T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes[J]. JOURNAL OF NATURAL PRODUCTS,2009,72(1):99-101.
APA Ding, Ling,Pfoh, Roland,Ruehl, Stephan,Qin, Song,Laatsch, Hartmut,&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2009).T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes.JOURNAL OF NATURAL PRODUCTS,72(1),99-101.
MLA Ding, Ling,et al."T-Muurolol Sesquiterpenes from the Marine Streptomyces sp M491 and Revision of the Configuration of Previously Reported Amorphanes".JOURNAL OF NATURAL PRODUCTS 72.1(2009):99-101.

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来源：海洋研究所

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