Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045
文献类型：期刊论文
| 作者 | Li, FC; Maskey, RP; Qin, S; Sattler, I; Fiebig, HH; Maier, A; Zeeck, A; Laatsch, H; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2005-03-01 |
| 卷号 | 68期号:3页码:349-353 |
| 关键词 | Manumycin |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np030518r |
| 文献子类 | Article |
| 英文摘要 | In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.; In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000227927700008 |
| 公开日期 | 2010-11-18 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/1630]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany |
| 作者单位 | 1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Oncotest GmbH, D-79108 Freiburg, Germany |
| 推荐引用方式 GB/T 7714 | Li, FC,Maskey, RP,Qin, S,et al. Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(3):349-353. |
| APA | Li, FC.,Maskey, RP.,Qin, S.,Sattler, I.,Fiebig, HH.,...&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2005).Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045.JOURNAL OF NATURAL PRODUCTS,68(3),349-353. |
| MLA | Li, FC,et al."Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045".JOURNAL OF NATURAL PRODUCTS 68.3(2005):349-353. |
入库方式： OAI收割
来源：海洋研究所
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