Genome-wide survey of putative serine/threonine protein kinases in cyanobacteria
文献类型：期刊论文
| 作者 | Zhang, Xiaowen; Zhao, Fangqing; Guan, Xiangyu; Yang, Yu; Liang, Chengwei; Qin, Song; Qin, S, Chinese Acad Sci, Inst Oceanol, Nanhai Rd, Qingdao, Peoples R China |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2007 |
| 卷号 | 8页码:395 |
| 关键词 | Sp Strain Pcc-7120 Synechocystis Sp Pcc-6803 Signal-transduction Sequence Alignment Catalytic Domain Sensory Domains Ser/thr Kinases Gaf Domain Fha Domain Bacteria |
| ISSN号 | 1471-2164 |
| 英文摘要 | Background: Serine/threonine kinases (STKs) have been found in an increasing number of prokaryotes, showing important roles in signal transduction that supplement the well known role of two-component system. Cyanobacteria are photoautotrophic prokaryotes able to grow in a wide range of ecological environments, and their signal transduction systems are important in adaptation to the environment. Sequence information from several cyanobacterial genomes offers a unique opportunity to conduct a comprehensive comparative analysis of this kinase family. In this study, we extracted information regarding Ser/Thr kinases from 21 species of sequenced cyanobacteria and investigated their diversity, conservation, domain structure, and evolution. Results: 286 putative STK homologues were identified. STKs are absent in four Prochlorococcus strains and one marine Synechococcus strain and abundant in filamentous nitrogen-fixing cyanobacteria. Motifs and invariant amino acids typical in eukaryotic STKs were conserved well in these proteins, and six more cyanobacteria- or bacteria-specific conserved residues were found. These STK proteins were classified into three major families according to their domain structures. Fourteen types and a total of 131 additional domains were identified, some of which are reported to participate in the recognition of signals or substrates. Cyanobacterial STKs show rather complicated phylogenetic relationships that correspond poorly with phylogenies based on 16S rRNA and those based on additional domains. Conclusion: The number of STK genes in different cyanobacteria is the result of the genome size, ecophysiology, and physiological properties of the organism. Similar conserved motifs and amino acids indicate that cyanobacterial STKs make use of a similar catalytic mechanism as eukaryotic STKs. Gene gain-and-loss is significant during STK evolution, along with domain shuffling and insertion. This study has established an overall framework of sequence-structure-function interactions for the STK gene family, which may facilitate further studies of the role of STKs in various organisms. |
| 学科主题 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| URL标识 | 查看原文 |
| 公开日期 | 2010-11-18 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/1738]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Qin, S, Chinese Acad Sci, Inst Oceanol, Nanhai Rd, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaowen,Zhao, Fangqing,Guan, Xiangyu,et al. Genome-wide survey of putative serine/threonine protein kinases in cyanobacteria[J]. BMC GENOMICS,2007,8:395. |
| APA | Zhang, Xiaowen.,Zhao, Fangqing.,Guan, Xiangyu.,Yang, Yu.,Liang, Chengwei.,...&Qin, S, Chinese Acad Sci, Inst Oceanol, Nanhai Rd, Qingdao, Peoples R China.(2007).Genome-wide survey of putative serine/threonine protein kinases in cyanobacteria.BMC GENOMICS,8,395. |
| MLA | Zhang, Xiaowen,et al."Genome-wide survey of putative serine/threonine protein kinases in cyanobacteria".BMC GENOMICS 8(2007):395. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。