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Sesquiterpenes from Laurencia similis

文献类型：期刊论文

作者Su, Hua1,2; Shi, Da-Yong1; Li, Jing1,2; Guo, Shu-Ju1,2; Li, Li-Li1,2; Yuan, Zhao-Hui1; Zhu, Xiao-Bin1; Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
刊名MOLECULES
出版日期2009-05-01
卷号14期号:5页码:1889-1897
关键词Laurencia Similis Sesquiterpenes Cytotoxic Assay
ISSN号1420-3049
DOI10.3390/molecules14051889
文献子类Article
英文摘要One new sesquiterpene, (4E)-1-bromo-5-[(1'S*, 3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1( 10)-en-9-ol (13), aristolan-1(10), 8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC(50) > 10 mu g/mL).; One new sesquiterpene, (4E)-1-bromo-5-[(1'S*, 3'R*)-3'-bromo-2',2'-dimethyl-6'-methylenecyclohexyl]-3-methylpent-4-ene-2,3-diol (1), and fifteen known sesquiterpenes, isopalisol (2), luzonensol (3), palisadin B (4), aplysistatin (5), palisadin A (6), 4-hydroxyl-palisudin C (7), 5-acetoxypalisadin B (8), 10-hydroxyaristolan-9-one (9), aristol-8-en-1-one (10), aristolan-9-en-1-one (11), aristolan-1(10)-en-9-one (12), aristolan-1( 10)-en-9-ol (13), aristolan-1(10), 8-diene (14), aristolan-1,9-diene (15) and aristofone (16), were isolated from a sample of marine red alga Laurencia similis. Their structures were established by detailed NMR spectroscopic analysis and comparison with literature data. Compounds 2-9, and 16 were isolated for the first time from this species. All these metabolites were submitted for a cytotoxicity assay against the tumor cell line BEL7402 (human liver adenocarcinoma), but all of them were found inactive (IC50 > 10 mu g/mL).
学科主题Chemistry, Organic
URL标识查看原文
语种英语
WOS记录号WOS:000266381200020
公开日期2010-11-18
源URL[http://ir.qdio.ac.cn/handle/337002/1881]  
专题海洋研究所_海洋生物技术研发中心
海洋研究所_实验海洋生物学重点实验室
通讯作者Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Su, Hua,Shi, Da-Yong,Li, Jing,et al. Sesquiterpenes from Laurencia similis[J]. MOLECULES,2009,14(5):1889-1897.
APA Su, Hua.,Shi, Da-Yong.,Li, Jing.,Guo, Shu-Ju.,Li, Li-Li.,...&Yuan, ZH, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.(2009).Sesquiterpenes from Laurencia similis.MOLECULES,14(5),1889-1897.
MLA Su, Hua,et al."Sesquiterpenes from Laurencia similis".MOLECULES 14.5(2009):1889-1897.

入库方式： OAI收割

来源：海洋研究所

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