Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus
文献类型：期刊论文
| 作者 | Cui, Chuan-Ming1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Sun, Hao-Fen1; Gan, Shu-Shan1,2; Wang, Bin-Gui1
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| 刊名 | HELVETICA CHIMICA ACTA
 |
| 出版日期 | 2009 |
| 卷号 | 92期号:7页码:1366-1370 |
| 关键词 | Niger En-13 Polysiphonia-urceolata Red Alga Circumdatin |
| ISSN号 | 0018-019X |
| 文献子类 | Article |
| 英文摘要 | A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC(50) value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.; A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC50 value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control. |
| 学科主题 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000268622500016 |
| 公开日期 | 2010-12-22 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/2891]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,et al. Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus[J]. HELVETICA CHIMICA ACTA,2009,92(7):1366-1370. |
| APA | Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,Sun, Hao-Fen,Gan, Shu-Shan,&Wang, Bin-Gui.(2009).Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus.HELVETICA CHIMICA ACTA,92(7),1366-1370. |
| MLA | Cui, Chuan-Ming,et al."Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus".HELVETICA CHIMICA ACTA 92.7(2009):1366-1370. |
入库方式： OAI收割
来源：海洋研究所
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