Genetic mechanisms of multi-antimicrobial resistance in a pathogenic Edwardsiella tarda strain
文献类型：期刊论文
| 作者 | Sun, Kun1,2; Wang, Hua-lei3; Zhang, Min1,2; Mao, Zhi-zhong1; Sun, Li1 |
| 刊名 | AQUACULTURE
 |
| 出版日期 | 2009-04-03 |
| 卷号 | 289期号:1-2页码:134-139 |
| 关键词 | Antimicrobial Resistance Genetic Exchange Gene Transfer Mobile Genetic Element Edwardsiella Tarda |
| ISSN号 | 0044-8486 |
| DOI | 10.1016/j.aquaculture.2008.12.021 |
| 文献子类 | Article |
| 英文摘要 | TX01, a pathogenic Edwardsiella tarda strain isolated from diseased fish at an epidemic-inflicted fish farm in China, exhibits resistance to multiple classes of antimicrobial agents. The genes (kn(R). catA3, and tet(A), respectively) encoding resistance to kanamycin, chloramphenicol, and tetracycline were cloned and found to be 99-100% identical to the corresponding genes carried by known plasmids and transposons of human, animal, and environmental isolates. Further study demonstrated that TX01 harbors a plasmid, pETX, which proved to be (i) the carrier of the tet and cut operons; (ii) a mobile genetic element that is capable of transferring between bacteria of different genera. These results, which, to our knowledge, documented for the first time the co-existence of chloramphenicol and tetracycline resistance determinants on a conjugative plasmid in a pathogenic E tarda strain, indicated that gene acquisition via horizontal transferring of pETX-like mobile genetic entities may have played an important part in the dissemination of antimicrobial resistance and that there have existed for some time widespread genetic exchanges between bacteria of human, animal/fish, and environmental origins. (C) 2008 Elsevier B.V. All rights reserved.; TX01, a pathogenic Edwardsiella tarda strain isolated from diseased fish at an epidemic-inflicted fish farm in China, exhibits resistance to multiple classes of antimicrobial agents. The genes (kn(R). catA3, and tet(A), respectively) encoding resistance to kanamycin, chloramphenicol, and tetracycline were cloned and found to be 99-100% identical to the corresponding genes carried by known plasmids and transposons of human, animal, and environmental isolates. Further study demonstrated that TX01 harbors a plasmid, pETX, which proved to be (i) the carrier of the tet and cut operons; (ii) a mobile genetic element that is capable of transferring between bacteria of different genera. These results, which, to our knowledge, documented for the first time the co-existence of chloramphenicol and tetracycline resistance determinants on a conjugative plasmid in a pathogenic E tarda strain, indicated that gene acquisition via horizontal transferring of pETX-like mobile genetic entities may have played an important part in the dissemination of antimicrobial resistance and that there have existed for some time widespread genetic exchanges between bacteria of human, animal/fish, and environmental origins. (C) 2008 Elsevier B.V. All rights reserved. |
| 学科主题 | Fisheries ; Marine & Freshwater Biology |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000264942400021 |
| 公开日期 | 2010-12-22 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/3015]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Hang Zhou EnzySource Biotechnol Co Ltd, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Kun,Wang, Hua-lei,Zhang, Min,et al. Genetic mechanisms of multi-antimicrobial resistance in a pathogenic Edwardsiella tarda strain[J]. AQUACULTURE,2009,289(1-2):134-139. |
| APA | Sun, Kun,Wang, Hua-lei,Zhang, Min,Mao, Zhi-zhong,&Sun, Li.(2009).Genetic mechanisms of multi-antimicrobial resistance in a pathogenic Edwardsiella tarda strain.AQUACULTURE,289(1-2),134-139. |
| MLA | Sun, Kun,et al."Genetic mechanisms of multi-antimicrobial resistance in a pathogenic Edwardsiella tarda strain".AQUACULTURE 289.1-2(2009):134-139. |
入库方式： OAI收割
来源：海洋研究所
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