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Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger

文献类型：期刊论文

作者Zhang, Yi; Li, Xiao-Ming; Proksch, Peter; Wang, Bin-Gui
刊名STEROIDS
出版日期2007-09-01
卷号72期号:9-10页码:723-727
关键词Brown Alga Colpomenia Sinuosa Endophytic Fungus Aspergillus Niger Ergosterimide Diels-alder Adduct
ISSN号0039-128X
DOI10.1016/j.steroids.2007.05.009
文献子类Article
英文摘要Ergosterimide (1), a natural Diels-Alder adduct of ergosteroid and maleimide, was characterized from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the marine brown alga Colpomenia sinuosa. In addition, four known steroids including (22E,24R)-ergosta-5,7,22-trien-3 beta-ol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3one (3), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (4), and (22E,24R)-ergosta-7,22dien-3 beta,5 alpha,6 beta-triol. (5) were also isolated and identified. The structures of these compounds were elucidated by extensive analysis of 1D and 2D NMR and IR spectra and MS data. The plausible biosynthetic pathway of 1 was also discussed. To the best of our knowledge, 1 is the first natural Diels-Alder adduct of steroid and maleimide reported so far. (C) 2007 Elsevier Inc. All rights reserved.; Ergosterimide (1), a natural Diels-Alder adduct of ergosteroid and maleimide, was characterized from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the marine brown alga Colpomenia sinuosa. In addition, four known steroids including (22E,24R)-ergosta-5,7,22-trien-3 beta-ol (2), (22E,24R)-ergosta-4,6,8(14),22-tetraen-3one (3), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (4), and (22E,24R)-ergosta-7,22dien-3 beta,5 alpha,6 beta-triol. (5) were also isolated and identified. The structures of these compounds were elucidated by extensive analysis of 1D and 2D NMR and IR spectra and MS data. The plausible biosynthetic pathway of 1 was also discussed. To the best of our knowledge, 1 is the first natural Diels-Alder adduct of steroid and maleimide reported so far. (C) 2007 Elsevier Inc. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Endocrinology & Metabolism
URL标识查看原文
语种英语
WOS记录号WOS:000249138700007
公开日期2010-12-24
源URL[http://ir.qdio.ac.cn/handle/337002/5731]  
专题海洋研究所_实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式
GB/T 7714		 Zhang, Yi,Li, Xiao-Ming,Proksch, Peter,et al. Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger[J]. STEROIDS,2007,72(9-10):723-727.
APA Zhang, Yi,Li, Xiao-Ming,Proksch, Peter,&Wang, Bin-Gui.(2007).Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger.STEROIDS,72(9-10),723-727.
MLA Zhang, Yi,et al."Ergosterimide, a new natural Diels-Alder adduct of a steroid and maleimide in the fungus Aspergillus niger".STEROIDS 72.9-10(2007):723-727.

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来源：海洋研究所

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