Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.
文献类型：期刊论文
| 作者 | Kwong, Theresa Fuk Ning; Miao, Li; Li, Xiancui; Qian, Pei Yuan |
| 刊名 | MARINE BIOTECHNOLOGY
 |
| 出版日期 | 2006-11-01 |
| 卷号 | 8期号:6页码:634-640 |
| 关键词 | Ampelomyces Antifouling Agent Antimicrobial Agent 3-chloro-2 5-dihydroxybenzyl Alcohol |
| ISSN号 | 1436-2228 |
| DOI | 10.1007/s10126-005-6146-2 |
| 文献子类 | Article |
| 英文摘要 | In this study, using a bioassay-guided isolation and purification procedure, we obtained 3-chloro-2,5-dihydroxybenzyl alcohol from a marine-derived Ampelomyces species that effectively inhibited larval settlement of the tubeworm Hydroides elegans and of cyprids of the barnacle Balanus amphitrite. The inhibitive effect on larval settlement was nontoxic and the EC50 of 3-chloro-2,5-dihydroxybenzyl alcohol ranged from 3.19 mu g ml(-1) to 3.81 mu g ml(-1) while the LC50 was 266.68 lambda g ml(-1) for B. amphitrite cyprids; EC50 ranged from 0.67 mu g ml(-1) to 0.78 mu g ml(-1), and LC50 was 2.64 mu g ml(-1) for competent larvae of H. elegans, indicating that inhibitive effect of this compound was nontoxic. At a concentration of 50 mu g per disc, this compound showed strong inhibitive effects on the growth of 13 out of 15 marine bacterial species tested in disc diffusion bioassay. Overall, the high inhibitory activities against bacteria and larval settlement as well as the non- or low-toxic nature of this compound to the barnacle and polychaete larvae suggest this compound could be a potent antifoulant and/or antibiotic.; In this study, using a bioassay-guided isolation and purification procedure, we obtained 3-chloro-2,5-dihydroxybenzyl alcohol from a marine-derived Ampelomyces species that effectively inhibited larval settlement of the tubeworm Hydroides elegans and of cyprids of the barnacle Balanus amphitrite. The inhibitive effect on larval settlement was nontoxic and the EC50 of 3-chloro-2,5-dihydroxybenzyl alcohol ranged from 3.19 mu g ml(-1) to 3.81 mu g ml(-1) while the LC50 was 266.68 lambda g ml(-1) for B. amphitrite cyprids; EC50 ranged from 0.67 mu g ml(-1) to 0.78 mu g ml(-1), and LC50 was 2.64 mu g ml(-1) for competent larvae of H. elegans, indicating that inhibitive effect of this compound was nontoxic. At a concentration of 50 mu g per disc, this compound showed strong inhibitive effects on the growth of 13 out of 15 marine bacterial species tested in disc diffusion bioassay. Overall, the high inhibitory activities against bacteria and larval settlement as well as the non- or low-toxic nature of this compound to the barnacle and polychaete larvae suggest this compound could be a potent antifoulant and/or antibiotic. |
| 学科主题 | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000243193200007 |
| 公开日期 | 2010-12-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/5963]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Coastal Marine Lab, Kowloon, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kwong, Theresa Fuk Ning,Miao, Li,Li, Xiancui,et al. Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.[J]. MARINE BIOTECHNOLOGY,2006,8(6):634-640. |
| APA | Kwong, Theresa Fuk Ning,Miao, Li,Li, Xiancui,&Qian, Pei Yuan.(2006).Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp..MARINE BIOTECHNOLOGY,8(6),634-640. |
| MLA | Kwong, Theresa Fuk Ning,et al."Novel antifouling and antimicrobial compound from a marine-derived fungus Ampelomyces sp.".MARINE BIOTECHNOLOGY 8.6(2006):634-640. |
入库方式： OAI收割
来源：海洋研究所
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