Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity
文献类型：期刊论文
| 作者 | Qi Huimin1,2; Li Daxin3; Zhang Jingjing1; Liu Li1 ; Zhang Quanbin1
|
| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2008-05-01 |
| 卷号 | 26期号:2页码:186-189 |
| 关键词 | Agar Gelidium Amansii Agaropectin Anticoagulation |
| ISSN号 | 0254-4059 |
| DOI | 10.1007/s00343-008-0186-1 |
| 文献子类 | Article |
| 英文摘要 | Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar, and named as agaropectin with sulfate content being 22.8% and 32.5%, respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100, 200, and 400 mg/kg.d in rats for 15 days, TT (thrombin time), CT (coagulation time), PT (prothrombin time), and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered.; Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar, and named as agaropectin with sulfate content being 22.8% and 32.5%, respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100, 200, and 400 mg/kg.d in rats for 15 days, TT (thrombin time), CT (coagulation time), PT (prothrombin time), and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered. |
| 学科主题 | Limnology ; Oceanography |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000256416000010 |
| 公开日期 | 2010-12-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/6083]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Weifang Med Univ, Weifang 261042, Peoples R China 3.Shandong Prov Pharmaceut Co, Jinan 250014, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi Huimin,Li Daxin,Zhang Jingjing,et al. Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2008,26(2):186-189. |
| APA | Qi Huimin,Li Daxin,Zhang Jingjing,Liu Li,&Zhang Quanbin.(2008).Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,26(2),186-189. |
| MLA | Qi Huimin,et al."Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 26.2(2008):186-189. |
入库方式： OAI收割
来源：海洋研究所
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