中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 海洋生物技术研发中心
热门
Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro

文献类型：期刊论文

作者Zhong, Zhimei1,2; Xing, Ronge1; Liu, Song1,2; Wang, Lin1,2; Cai, Shengbao1,2; Li, Pengcheng1,2
刊名CARBOHYDRATE RESEARCH
出版日期2008-02-25
卷号343期号:3页码:566-570
关键词Antibacterial Activity Antifungal Activity Chitosan Acyl Thiourea Derivatives
ISSN号0008-6215
DOI10.1016/j.carres.2007.11.024
文献子类Article
英文摘要Three different acyl thiourea derivatives of chitosan (CS) were synthesized and their structures were characterized by FT-IR spectroscopy and elemental analysis. The antimicrobial behaviors of CS and its derivatives against four species of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Sarcina) and four crop-threatening pathogenic fungi (Alternaria solani, Fusarium oxysporum f. sp. vasinfectum, Colletotrichum gloeosporioides (Penz.) Saec, and Phyllisticta zingiberi) were investigated. The results indicated that the antimicrobial activities of the acyl thiourea derivatives are much better than that of the parent CS. The minimum value of MIC and MBC of the derivatives against E coli was 15.62 and 62.49 mu g/mL, respectively. All of the acyl thiourea derivatives had a significant inhibitory effect on the fungi in concentrations of 50 - 500 mu g/mL; the maximum inhibitory index was 66.67%. The antifungal activities of the chloracetyl thiourea derivatives of CS are noticeably higher than the acetyl and benzoyl thiourea derivatives. The degree of grafting of the acyl thiourea group in the derivatives was related to antifungal activity; higher substitution resulted in stronger antifungal activity. (c) 2007 Elsevier Ltd. All rights reserved.; Three different acyl thiourea derivatives of chitosan (CS) were synthesized and their structures were characterized by FT-IR spectroscopy and elemental analysis. The antimicrobial behaviors of CS and its derivatives against four species of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Sarcina) and four crop-threatening pathogenic fungi (Alternaria solani, Fusarium oxysporum f. sp. vasinfectum, Colletotrichum gloeosporioides (Penz.) Saec, and Phyllisticta zingiberi) were investigated. The results indicated that the antimicrobial activities of the acyl thiourea derivatives are much better than that of the parent CS. The minimum value of MIC and MBC of the derivatives against E coli was 15.62 and 62.49 mu g/mL, respectively. All of the acyl thiourea derivatives had a significant inhibitory effect on the fungi in concentrations of 50 - 500 mu g/mL; the maximum inhibitory index was 66.67%. The antifungal activities of the chloracetyl thiourea derivatives of CS are noticeably higher than the acetyl and benzoyl thiourea derivatives. The degree of grafting of the acyl thiourea group in the derivatives was related to antifungal activity; higher substitution resulted in stronger antifungal activity. (c) 2007 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
URL标识查看原文
语种英语
WOS记录号WOS:000253667500019
公开日期2010-12-24
源URL[http://ir.qdio.ac.cn/handle/337002/6131]  
专题海洋研究所_海洋生物技术研发中心
海洋研究所_实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Zhong, Zhimei,Xing, Ronge,Liu, Song,et al. Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro[J]. CARBOHYDRATE RESEARCH,2008,343(3):566-570.
APA Zhong, Zhimei,Xing, Ronge,Liu, Song,Wang, Lin,Cai, Shengbao,&Li, Pengcheng.(2008).Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro.CARBOHYDRATE RESEARCH,343(3),566-570.
MLA Zhong, Zhimei,et al."Synthesis of acyl thiourea derivatives of chitosan and their antimicrobial activities in vitro".CARBOHYDRATE RESEARCH 343.3(2008):566-570.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。