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Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula

文献类型：期刊论文

作者Liu Xu1,2; Li Xiaoming1; Gao Lixin3; Cui Chuanming1,2; Li Chunshun1; Li Jia3; Wang Bingui1
刊名CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
出版日期2011-05-01
卷号29期号:3页码:686-690
关键词Marine Alga Rhodomelaceae Symphyocladia Latiuscula Bromophenol Protein Tyrosine Phosphatase 1b (Ptp1b)
ISSN号0254-4059
DOI10.1007/s00343-011-0136-1
文献子类Article
英文摘要Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl) methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC(50) values of 3.9, 4.3, and 3.5 mu mol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs.; Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl) methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC(50) values of 3.9, 4.3, and 3.5 mu mol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs.
学科主题Marine & Freshwater Biology ; Oceanography
URL标识查看原文
语种英语
WOS记录号WOS:000292558100024
公开日期2012-07-03
源URL[http://ir.qdio.ac.cn/handle/337002/11860]  
专题海洋研究所_实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Liu Xu,Li Xiaoming,Gao Lixin,et al. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2011,29(3):686-690.
APA Liu Xu.,Li Xiaoming.,Gao Lixin.,Cui Chuanming.,Li Chunshun.,...&Wang Bingui.(2011).Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,29(3),686-690.
MLA Liu Xu,et al."Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 29.3(2011):686-690.

入库方式： OAI收割

来源：海洋研究所

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