中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 海洋研究所
  3. 中国科学院海洋研究所
  4. 实验海洋生物学重点实验室
Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132

文献类型：期刊论文

作者Liu, Dong2,3; Li, Xiao-Ming2; Meng, Li1; Li, Chun-Shun2; Gao, Shu-Shan2,3; Shang, Zhuo2,3; Proksch, Peter4; Huang, Cai-Guo1; Wang, Bin-Gui2
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2011-08-01
卷号74期号:8页码:1787-1791
ISSN号0163-3864
DOI10.1021/np200381u
文献子类Article
英文摘要Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.; Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.
学科主题Plant Sciences ; Pharmacology & Pharmacy
URL标识查看原文
语种英语
WOS记录号WOS:000294242800016
公开日期2012-07-03
源URL[http://ir.qdio.ac.cn/handle/337002/11908]  
专题海洋研究所_实验海洋生物学重点实验室
作者单位1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式
GB/T 7714		 Liu, Dong,Li, Xiao-Ming,Meng, Li,et al. Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(8):1787-1791.
APA Liu, Dong.,Li, Xiao-Ming.,Meng, Li.,Li, Chun-Shun.,Gao, Shu-Shan.,...&Wang, Bin-Gui.(2011).Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.JOURNAL OF NATURAL PRODUCTS,74(8),1787-1791.
MLA Liu, Dong,et al."Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".JOURNAL OF NATURAL PRODUCTS 74.8(2011):1787-1791.

入库方式： OAI收割

来源：海洋研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。