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Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S

文献类型：期刊论文

作者Gao, Shu-Shan1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Proksch, Peter3; Wang, Bin-Gui1
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
出版日期2011-05-15
卷号21期号:10页码:2894-2897
ISSN号0960-894X
关键词Marine Endophyte Penicillium Chrysogenum Polyoxygenated Steroid Antifungal Activity Cytotoxic Activity
DOI10.1016/j.bmcl.2011.03.076
文献子类Article
英文摘要Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved.; Two new polyoxygenated steroids, namely, penicisteroids A and B (1 and 2), were obtained from the culture extract of Penicillium chrysogenum QEN-24S, an endophytic fungus isolated from an unidentified marine red algal species of the genus Laurencia. In addition, seven known steroids (3-9) were also isolated and identified. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configuration for compound 1 was determined by application of the modified Mosher's method. Penicisteroid A (1), which is a structurally unique steroid having tetrahydroxy and C-16-acetoxy groups, displayed potent antifungal and cytotoxic activity in the preliminary bioassays. Preliminary structure-activity relationships are discussed. (C) 2011 Elsevier Ltd. All rights reserved.
学科主题Pharmacology & Pharmacy ; Chemistry
URL标识查看原文
语种英语
WOS记录号WOS:000290024200021
公开日期2012-07-03
源URL[http://ir.qdio.ac.cn/handle/337002/11912]  
专题海洋研究所_实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式
GB/T 7714		 Gao, Shu-Shan,Li, Xiao-Ming,Li, Chun-Shun,et al. Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011,21(10):2894-2897.
APA Gao, Shu-Shan,Li, Xiao-Ming,Li, Chun-Shun,Proksch, Peter,&Wang, Bin-Gui.(2011).Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,21(10),2894-2897.
MLA Gao, Shu-Shan,et al."Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21.10(2011):2894-2897.

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来源：海洋研究所

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