Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain
文献类型：期刊论文
| 作者 | Tong, Hsin-I1,3; Kang, Wen1,2; Zhou, Guangzhou1,4; Liu, Min1,5; Shi, Yingli1,6 ; Lu, Yuanan1
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| 刊名 | CURRENT GENE THERAPY
 |
| 出版日期 | 2016 |
| 卷号 | 16期号:6页码:401-409 |
| 关键词 | Monocyte Non-invasive Delivery Cell-based Delivery System Gene Therapy Brain Neuroinflammation |
| DOI | 10.2174/1566523217666161118165710 |
| 文献子类 | Article |
| 英文摘要 | Objective: This study was aimed to explore the potential of a non-invasive monocytes-based delivery system to transport therapeutic genes into the diseased brain. The study was conducted by first establishing the optimized conditions for lentiviral vector (LV)-mediated gene transfer into freshly isolated monocytes, followed by investigating the inflamed-brain homing efficiency and in vivo cell-mediated transgene expression by carrier monocytes in a mouse model with acute sub-regional neuroinflammation. |
| 语种 | 英语 |
| WOS记录号 | WOS:000399786700004 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/136712]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Univ Hawaii Manoa, Off Publ Hlth Studies, Honolulu, HI 96822 USA 2.Fourth Mil Med Univ, Tangdu Hosp, Dept Infect Dis, Xian, Shaanxi, Peoples R China 3.Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA 4.Henan Univ Technol, Coll Bioengn, Zhengzhou, Henan, Peoples R China 5.Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 1, Dept Infect Dis, Xian, Shaanxi, Peoples R China 6.Chinese Acad Sci, Inst Oceanol, Qingdao, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,et al. Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain[J]. CURRENT GENE THERAPY,2016,16(6):401-409. |
| APA | Tong, Hsin-I,Kang, Wen,Zhou, Guangzhou,Liu, Min,Shi, Yingli,&Lu, Yuanan.(2016).Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain.CURRENT GENE THERAPY,16(6),401-409. |
| MLA | Tong, Hsin-I,et al."Evaluation on Monocyte-Mediated Delivery of a Therapeutic Gene into the Inflamed Brain".CURRENT GENE THERAPY 16.6(2016):401-409. |
入库方式： OAI收割
来源：海洋研究所
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