Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans
文献类型：期刊论文
| 作者 | Zhang, Enhui1,2,3 ; Xing, Ronge1,3; Liu, Song1,3; Li, Kecheng1,3; Qin, Yukun1,3; Yu, Huahua1,3; Li, Pengcheng1,3
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 101页码:1012-1018 |
| 关键词 | Carboxymethyl Chitosan Nanoparticle Anti-tumor |
| DOI | 10.1016/j.ijbiomac.2017.03.195 |
| 文献子类 | Article |
| 英文摘要 | In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs). Furthermore, the in vitro drug release profiles of all the three kinds of nanoparticles showed a sustained release behavior and the release rate of OC-NPs was the fastest. Moreover, compared with NC-NPs and NOC-NPs, OC-NPs exhibited more cellular accumulation in the human gastric carcinoma cells (SGC 7901) as quantitatively determined by the flow cytometry and also much stronger cytotoxicity against these cells. Accordingly, our results showed that drug-loaded nanoparticles formed by different CMCs have dissimilar physiochemical characteristics which subsequently influence their" therapeutic effects. We suggest that OC-based nanoparticle is a more desirable anti-tumor drug delivery system than NC-NP and NOC-NP. (C) 2017 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000404491300110 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/137032]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_实验海洋生物学重点实验室 海洋研究所_海洋环境工程技术研究发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,101:1012-1018. |
| APA | Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2017).Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,101,1012-1018. |
| MLA | Zhang, Enhui,et al."Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 101(2017):1012-1018. |
入库方式： OAI收割
来源：海洋研究所
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