Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva
文献类型：期刊论文
| 作者 | Li Rongfeng1; Yu Huahua1 ; Yue Yang1,2; Liu Song1; Xing Rong'e1; Chen Xiaolin1; Li Pengcheng1
|
| 刊名 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2017-07-01 |
| 卷号 | 35期号:4页码:763-769 |
| 关键词 | Sulfated Polysaccharides Sea Cucumber Holothuria Fuscogliva Antioxidant Activity Anticoagulant Activity |
| DOI | 10.1007/s00343-017-5339-7 |
| 文献子类 | Article |
| 英文摘要 | Sea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China. Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides. To investigate the bioactivities of the polysaccharides from sea cucumber H. fuscogliva, we prepared the sulfated polysaccharides (HfP) from sea cucumber H. fuscogliva using a protease hydrolysis method. Antioxidant activities of HfP were investigated, including hydroxyl radical scavenging activity and superoxide radical scavenging activity. And, the anticoagulant activities of HfP were studied, including the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT). The average molecular weight was 1 867.1 Da, with a sulfate content of 20.7%. In addition, the molar ratio of monosaccharide composition of HfP was Man: Rha: Glc A: Glc: Gal: Xyl: Fuc=0.083 6: 0.437: 0.134: 0:1.182: 0.748: 1. It had a strong antioxidant activity, the hydroxyl and superoxide radical scavenging activity EC50 of HfP was 3.74 and 0.037 mg/mL, respectively. It also showed a good anticoagulant activity in our study. The APTT of HfP was much higher than that of heparin sodium, and the PT and TT of HfP was close to that of heparin sodium at a low concentration. Therefore, HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry. |
| 语种 | 英语 |
| WOS记录号 | WOS:000403701200006 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/137126]  |
| 专题 | 海洋研究所_海洋环境工程技术研究发展中心 海洋研究所_实验海洋生物学重点实验室 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Rongfeng,Yu Huahua,Yue Yang,et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2017,35(4):763-769. |
| APA | Li Rongfeng.,Yu Huahua.,Yue Yang.,Liu Song.,Xing Rong'e.,...&Li Pengcheng.(2017).Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,35(4),763-769. |
| MLA | Li Rongfeng,et al."Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 35.4(2017):763-769. |
入库方式： OAI收割
来源：海洋研究所
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