Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus
文献类型：期刊论文
| 作者 | Kong, Fan-Dong1; Zhang, Ren-Shuai3; Ma, Qing-Yun1; Xie, Qing-Yi1; Wang, Pei1; Chen, Peng-Wei1; Zhou, Li-Man1; Dai, Hao-Fu1; Luo, Du-Qiang2; Zhao, You-Xing1 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 122页码:1-6 |
| 关键词 | Penicillitun Sp. Chrodrimanins Fungus Protein Tyrosine Phosphatase 1b Inhibition |
| DOI | 10.1016/j.fitote.2017.08.002 |
| 文献子类 | Article |
| 英文摘要 | Five new meroterpenoids, chrodrimanins O-S (1-5), as well as a known one (6), were isolated from the fermentation broth of Penicillium sp. SCS-ICED09 isolated from a marine worm, Sipunculusnudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Among them, compound 1 represents the first example of an unusual trichlorinated meroterpenoid with an unique dichlorine functionality. Compounds 1 and 4-6 displayed inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 71.6, 62.5, 63.1, and 39.6 mu M, respectively, and showed no apparent activity against three tumor cell lines (A549, HepG2, and Hela) and human umbilical vein endothelial cells (HUVEC) at 10 mu M. |
| 语种 | 英语 |
| WOS记录号 | WOS:000413383500001 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/143046]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Hainan, Peoples R China 2.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kong, Fan-Dong,Zhang, Ren-Shuai,Ma, Qing-Yun,et al. Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus[J]. FITOTERAPIA,2017,122:1-6. |
| APA | Kong, Fan-Dong.,Zhang, Ren-Shuai.,Ma, Qing-Yun.,Xie, Qing-Yi.,Wang, Pei.,...&Zhao, You-Xing.(2017).Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus.FITOTERAPIA,122,1-6. |
| MLA | Kong, Fan-Dong,et al."Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus".FITOTERAPIA 122(2017):1-6. |
入库方式： OAI收割
来源：海洋研究所
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