Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis
文献类型：期刊论文
| 作者 | Liu, Changshui1,2; Ding, Yamei2; Xian, Mo1; Liu, Min1; Liu, Huizhou1; Ma, Qingjun2; Zhao, Guang1 |
| 刊名 | CRITICAL REVIEWS IN BIOTECHNOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 37期号:7页码:933-941 |
| 关键词 | 3-hydroxypropionate Malonyl-coa Pathway Metabolic Engineering Acetyl-coa Carboxylase Malonyl-coa Reductase Carbon Flux Enzyme Engineering Supply Of Energy And cOfactor 3hp Tolerance |
| DOI | 10.1080/07388551.2016.1272093 |
| 文献子类 | Review |
| 英文摘要 | 3-Hydroxypropionate (3HP) is an attractive platform chemical, serving as a precursor to a variety of commodity chemicals like acrylate and acrylamide, as well as a monomer of a biodegradable plastic. To establish a sustainable way to produce these commercially important chemicals and materials, fermentative production of 3HP is widely investigated in recent years. It is reported that 3HP can be produced from several intermediates, such as glycerol, malonyl-CoA, and beta-alanine. Among all these biosynthetic routes, the malonyl-CoA pathway has some distinct advantages, including a broad feedstock spectrum, thermodynamic feasibility, and redox neutrality. To date, this pathway has been successfully constructed in various species including Escherichia coli, yeast and cyanobacteria, and optimized through carbon flux redirection, enzyme screening and engineering, and an increasing supply of energy and cofactors, resulting in significantly enhanced 3HP titer up to 40 g/L. These results show the feasibility of commercial manufacturing of 3HP and its derivatives in the future. |
| 语种 | 英语 |
| WOS记录号 | WOS:000407365200009 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/143082]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Changshui,Ding, Yamei,Xian, Mo,et al. Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2017,37(7):933-941. |
| APA | Liu, Changshui.,Ding, Yamei.,Xian, Mo.,Liu, Min.,Liu, Huizhou.,...&Zhao, Guang.(2017).Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis.CRITICAL REVIEWS IN BIOTECHNOLOGY,37(7),933-941. |
| MLA | Liu, Changshui,et al."Malonyl-CoA pathway: a promising route for 3-hydroxypropionate biosynthesis".CRITICAL REVIEWS IN BIOTECHNOLOGY 37.7(2017):933-941. |
入库方式： OAI收割
来源：海洋研究所
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