Crystal structures of the isochorismatase domains from Vibrio anguillarum
文献类型：期刊论文
| 作者 | Du, Jiansen1,2; Deng, Tian1,2; Ma, Qingjun1,2 |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2017-08-26 |
| 卷号 | 490期号:3页码:827-833 |
| 关键词 | Vibrio Isochorismatase Unknown Electron Density Antivirulence Inhibitor Aquaculture Disease |
| DOI | 10.1016/j.bbrc.2017.06.125 |
| 文献子类 | Article |
| 英文摘要 | Antibiotic resistance is becoming a global threat and overuse of antibiotics in aquaculture disease control worsens the situation. To reduce the risk of drug resistance developed in aquaculture, safer biocontrol programs are needed. Antivirulence therapy, with less chance for developing drug resistance, is a promising approach. To facilitate antivirulence inhibitor design against Vibrio anguillarum, a serious aquaculture pathogen, we present crystal structures for isochorismatase domains of AngB and VabB, which are required to synthesize siderophore, a critical virulence factor. Both structures are highly similar to known isochorismatases in fold and active site, therefore we conclude inhibitors for isochorismatases can be developed in a common framework. The structural information will improve design of virulence inhibitors against Vibrio anguillarum. We also firstly report that isochorismatase family could bind endogenous metabolite during the hetero-expression process, which is likely nicotinic acid, nicotinamide or pyrazinic acid, based on structural analysis and affinity prediction. Taken together, our results provide precise structural information of isochorismatase domains for antivirulence inhibitor design against Vibrio anguillarum. (C) 2017 Elsevier Inc. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000406820600037 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/143088]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Jiansen,Deng, Tian,Ma, Qingjun. Crystal structures of the isochorismatase domains from Vibrio anguillarum[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,490(3):827-833. |
| APA | Du, Jiansen,Deng, Tian,&Ma, Qingjun.(2017).Crystal structures of the isochorismatase domains from Vibrio anguillarum.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,490(3),827-833. |
| MLA | Du, Jiansen,et al."Crystal structures of the isochorismatase domains from Vibrio anguillarum".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 490.3(2017):827-833. |
入库方式： OAI收割
来源：海洋研究所
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