Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis
文献类型：期刊论文
| 作者 | Jiang, Shuai1,2; Sun, Li1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2017-09-01 |
| 卷号 | 18期号:9 |
| 关键词 | Cd209 Lectin Cynoglossus Semilaevis Microbial Recognition Phagocytosis |
| DOI | 10.3390/ijms18091848 |
| 文献子类 | Article |
| 英文摘要 | CD209 is an immune receptor that plays an important role in the initiation of innate immunity and activation of adaptive immunity in mammals. However, much less is known about the immunological function of CD209 in lower vertebrates. In the present study, we examined the immune effect of a CD209 homologue (CsCD209) from the teleost fish tongue sole Cynoglossus semilaevis. CsCD209 possesses a lectin domain that shares high levels of similarity with the lectin domains of human and mouse CD209. CsCD209 expression was most abundant in kidney and blood and was significantly upregulated during bacterial infection. CsCD209 exhibited a subcellular localization mainly on the cell surface of myelomonocytes. Recombinant CsCD209 displayed apparent binding capacities to a broad range of bacteria and fungi, and significantly promoted the phagocytosis of the bound bacteria by C. semilaevis leukocytes. Collectively, the results indicate that teleost CD209 serves as a pattern recognition receptor that exerts an influence on the phagocytosis process during pathogen infections. |
| 语种 | 英语 |
| WOS记录号 | WOS:000411963800027 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/143226]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Shuai,Sun, Li. Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017,18(9). |
| APA | Jiang, Shuai,&Sun, Li.(2017).Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,18(9). |
| MLA | Jiang, Shuai,et al."Tongue Sole CD209: A Pattern-Recognition Receptor that Binds a Broad Range of Microbes and Promotes Phagocytosis".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18.9(2017). |
入库方式： OAI收割
来源：海洋研究所
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