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Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats

文献类型：期刊论文

作者Li, N; Zhang, QB; Song, JM
刊名FOOD AND CHEMICAL TOXICOLOGY
出版日期2005-03-01
卷号43期号:3页码:421-426
关键词Fucoidan Laminaria Japonica Acute/subchronic Toxicity Rats
ISSN号0278-6915
DOI10.1016/j.fct.2004.12.001
文献子类Article
英文摘要Fucoidans, the sulfated polysacchrides extracted from brown algae, have been extensively studied for their diverse biological activities. However, there is no detailed report investigating the toxicity of fucoidan. In this study, the acute and subchronic (6 months) toxicity of varying levels of fucoidan extracted from Laminaria japonica was investigated in Wistar rats after oral administration. The results showed that no significant toxicological changes were observed when 300 mg/kg body weight per day fucoidan was administered to rats. But when the dose was increased to 900 and 2500 mg/kg body weight per day, the clotting time was significantly prolonged. Besides this, no other signs of toxicity were observed. Based on these results, it can be concluded that the no adverse effect level of fucoidan from L. japonica is 300 mg/kg body weight per day. (C) 2004 Elsevier Ltd. All rights reserved.; Fucoidans, the sulfated polysacchrides extracted from brown algae, have been extensively studied for their diverse biological activities. However, there is no detailed report investigating the toxicity of fucoidan. In this study, the acute and subchronic (6 months) toxicity of varying levels of fucoidan extracted from Laminaria japonica was investigated in Wistar rats after oral administration. The results showed that no significant toxicological changes were observed when 300 mg/kg body weight per day fucoidan was administered to rats. But when the dose was increased to 900 and 2500 mg/kg body weight per day, the clotting time was significantly prolonged. Besides this, no other signs of toxicity were observed. Based on these results, it can be concluded that the no adverse effect level of fucoidan from L. japonica is 300 mg/kg body weight per day. (C) 2004 Elsevier Ltd. All rights reserved.
学科主题Food Science & Technology ; Toxicology
URL标识查看原文
语种英语
WOS记录号WOS:000226962400004
公开日期2010-12-22
源URL[http://ir.qdio.ac.cn/handle/337002/3517]  
专题海洋研究所_海洋生物技术研发中心
海洋研究所_海洋生态与环境科学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Li, N,Zhang, QB,Song, JM. Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2005,43(3):421-426.
APA Li, N,Zhang, QB,&Song, JM.(2005).Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,43(3),421-426.
MLA Li, N,et al."Toxicological evaluation of fucoidan extracted from Laminaria japonica in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 43.3(2005):421-426.

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来源：海洋研究所

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