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Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides

文献类型：期刊论文

作者Yuan, Huamao; Song, Jinming; Li, Xuegang; Li, Ning; Dai, Jicui
刊名CANCER LETTERS
出版日期2006-11-18
卷号243期号:2页码:228-234
关键词Carrageenan Oligosaccharides Antitumor Immunomodulation
ISSN号0304-3835
DOI10.1016/j.canlet.2005.11.032
文献子类Article
英文摘要The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.; The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
学科主题Oncology
URL标识查看原文
语种英语
WOS记录号WOS:000242481900008
公开日期2010-12-24
源URL[http://ir.qdio.ac.cn/handle/337002/5489]  
专题海洋研究所_海洋生态与环境科学重点实验室
作者单位1.Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China
2.Acad Sinica, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Huamao,Song, Jinming,Li, Xuegang,et al. Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides[J]. CANCER LETTERS,2006,243(2):228-234.
APA Yuan, Huamao,Song, Jinming,Li, Xuegang,Li, Ning,&Dai, Jicui.(2006).Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides.CANCER LETTERS,243(2),228-234.
MLA Yuan, Huamao,et al."Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides".CANCER LETTERS 243.2(2006):228-234.

入库方式： OAI收割

来源：海洋研究所

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