中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry

文献类型:期刊论文

作者Jia, Lewen1,2; Wang, Chang1; Zhao, Sumin1; Lu, Xin1; Xu, Guowang1
刊名journal of chromatography b-analytical technologies in the biomedical and life sciences
出版日期2007-12-01
卷号860期号:1页码:134-140
关键词phospholipids chronic glomerulonephritis high performance liquid chromatography mass spectrometry
产权排序1;1
通讯作者许国旺
英文摘要plasma phospholipids metabolic profile of chronic glomerulonephritis was investigated using high performance liquid chromatography/mass spectrometry (lu/ms) and principal component analysis. the plasma samples of 18 patients with chronic glomerulonephritis, 17 patients with chronic renal failure (crf) without renal replacement therapy and 18 healthy persons were collected and analyzed. it was found that combination of the lc/ms technique with pca can be successfully applied to phospholipid profile analysis. the results showed that primary chronic glomerulonephritis and crf had phospholipids metabolic abnormality. nineteen phospholipid species were identified as possible biomarkers in plasma samples of chronic glomerulonephritis and chronic renal failure. moreover, the identification of the molecular structure of the potential phospholipid markers was obtained by esi-ms/ms experiment. it suggests that phospholipids can be used as potential biomarkers on the progress of primary chronic glomerulonephritis. (c) 2007 elsevier b.v. all rights reserved.
WOS标题词science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]biochemical research methods ; chemistry, analytical
研究领域[WOS]biochemistry & molecular biology ; chemistry
关键词[WOS]protein-kinase-c ; multivariate statistical-analysis ; rat urine ; metabonomics ; activation ; isoforms ; pathway ; systems
收录类别SCI
原文出处true
语种英语
WOS记录号WOS:000251852500019
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/99543]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China
2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China
推荐引用方式
GB/T 7714
Jia, Lewen,Wang, Chang,Zhao, Sumin,et al. Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2007,860(1):134-140.
APA Jia, Lewen,Wang, Chang,Zhao, Sumin,Lu, Xin,&Xu, Guowang.(2007).Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,860(1),134-140.
MLA Jia, Lewen,et al."Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 860.1(2007):134-140.

入库方式: OAI收割

来源:大连化学物理研究所

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