Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Jia, Lewen1,2; Wang, Chang1; Zhao, Sumin1; Lu, Xin1; Xu, Guowang1 |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 860期号:1页码:134-140 |
| 关键词 | phospholipids chronic glomerulonephritis high performance liquid chromatography mass spectrometry |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | plasma phospholipids metabolic profile of chronic glomerulonephritis was investigated using high performance liquid chromatography/mass spectrometry (lu/ms) and principal component analysis. the plasma samples of 18 patients with chronic glomerulonephritis, 17 patients with chronic renal failure (crf) without renal replacement therapy and 18 healthy persons were collected and analyzed. it was found that combination of the lc/ms technique with pca can be successfully applied to phospholipid profile analysis. the results showed that primary chronic glomerulonephritis and crf had phospholipids metabolic abnormality. nineteen phospholipid species were identified as possible biomarkers in plasma samples of chronic glomerulonephritis and chronic renal failure. moreover, the identification of the molecular structure of the potential phospholipid markers was obtained by esi-ms/ms experiment. it suggests that phospholipids can be used as potential biomarkers on the progress of primary chronic glomerulonephritis. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | protein-kinase-c ; multivariate statistical-analysis ; rat urine ; metabonomics ; activation ; isoforms ; pathway ; systems |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000251852500019 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/99543]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Lewen,Wang, Chang,Zhao, Sumin,et al. Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2007,860(1):134-140. |
| APA | Jia, Lewen,Wang, Chang,Zhao, Sumin,Lu, Xin,&Xu, Guowang.(2007).Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,860(1),134-140. |
| MLA | Jia, Lewen,et al."Metabolomic identification of potential phospholipid biomarkers for chronic glomerulonephritis by using high performance liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 860.1(2007):134-140. |
入库方式： OAI收割
来源：大连化学物理研究所
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