An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst
文献类型：期刊论文
| 作者 | Zhang, Yanmei; Li, Jun; Han, Difei; Zhang, Huidong; Liu, Peng; Li, Can |
| 刊名 | biochemical and biophysical research communications
 |
| 出版日期 | 2008-01-25 |
| 卷号 | 365期号:4页码:609-613 |
| 关键词 | magnetic nanoparticles siliceous mesocellular foam octyl groups hydrophobic surface lipase pseudomonas cepacia hyper-activation racemic alcohols recycling |
| 产权排序 | 1;1 |
| 通讯作者 | 李灿 |
| 英文摘要 | the combination of magnetic nanoparticles and mesoporous silica can present a strategy for enzyme immobilization. in this work, magnetic siliceous mesocellular foam functionalized with octyl groups was prepared and used as support for lipase adsorption. almost all the active lipases in crude enzyme solution were adsorbed by this magnetically separable, hydrophobic siliceous mesocellular foam. the resolution of 1-phenylethanol acylated with vinyl acetate can be achieved in 1.5 h using the resultant magnetic biocatalyst, whereas only 30% conversion was obtained by using the free lipase under the identical reaction conditions. these results are probably due to the "interfacial adsorption" and "hyper-activation" of lipase on the hydrophobic surface of the magnetic siliceous mesocellular foam. moreover, the biocatalyst entrapped in the nanopores of this foam can be recycled magnetically for at least seven times without significant loss of its activity and enantioselectivity. (c) 2007 elsevier inc. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; biophysics |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics |
| 关键词[WOS] | mesocellular mesoporous silica ; interfacial adsorption ; hydrophobic supports ; pseudomonas-cepacia ; immobilization ; nanoparticles ; enzymes ; lipase ; nanocomposites ; stabilization |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000251867100002 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/99655]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yanmei,Li, Jun,Han, Difei,et al. An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst[J]. biochemical and biophysical research communications,2008,365(4):609-613. |
| APA | Zhang, Yanmei,Li, Jun,Han, Difei,Zhang, Huidong,Liu, Peng,&Li, Can.(2008).An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst.biochemical and biophysical research communications,365(4),609-613. |
| MLA | Zhang, Yanmei,et al."An efficient resolution of racemic secondary alcohols on magnetically separable biocatalyst".biochemical and biophysical research communications 365.4(2008):609-613. |
入库方式： OAI收割
来源：大连化学物理研究所
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