Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution
文献类型：期刊论文
| 作者 | Guo, Yong-Xue; Xiu, Zhi-Long; Zhang, Dai-Jia; Wang, Hui; Wang, Long-Xing; Xiao, Hong-Bin |
| 刊名 | journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2007-03-12 |
| 卷号 | 43期号:4页码:1249-1255 |
| 关键词 | lithospermic acid B kinetics reaction mechanism hydrolysis LC-MS |
| 产权排序 | 2;5 |
| 通讯作者 | zhi-long xiu |
| 英文摘要 | the degradation of lithospermic acid b (lab) was investigated as a function of buffer concentration, ph and temperature. stability tests were performed using a stability-indicating high-performance liquid chromatography (hplc) with uv-vis detection. the degradation followed pseudo-first-order kinetics under all experimental conditions. the maximum stability of lab was observed at ph 2.0. the log k(ph)-ph profile described by specific acid-base catalysis and water molecules agreed with the experimental results. the overall degradation rate constant as a function of the temperature under the given conditions obeyed the arrhenius equation. the chemical fate of lab in mild acidic solution was investigated, and nine degradation products were detected and tentatively identified by lc-ms analysis. the primary degradation pathway involving the cleavage of ester bond and ring-opened of benzofuran in the lab are proposed. (c) 2006 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences ; life sciences & biomedicine |
| 类目[WOS] | chemistry, analytical ; pharmacology & pharmacy |
| 研究领域[WOS] | chemistry ; pharmacology & pharmacy |
| 关键词[WOS] | salvia-miltiorrhiza ; inhibition ; radix ; rats |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000245262300008 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/99755]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yong-Xue,Xiu, Zhi-Long,Zhang, Dai-Jia,et al. Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution[J]. journal of pharmaceutical and biomedical analysis,2007,43(4):1249-1255. |
| APA | Guo, Yong-Xue,Xiu, Zhi-Long,Zhang, Dai-Jia,Wang, Hui,Wang, Long-Xing,&Xiao, Hong-Bin.(2007).Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution.journal of pharmaceutical and biomedical analysis,43(4),1249-1255. |
| MLA | Guo, Yong-Xue,et al."Kinetics and mechanism of degradation of lithospermic acid B in aqueous solution".journal of pharmaceutical and biomedical analysis 43.4(2007):1249-1255. |
入库方式： OAI收割
来源：大连化学物理研究所
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