Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine
文献类型：期刊论文
| 作者 | Wang, Jing1 ; Zhang, Quanbin1; Jin, Weihua1,2; Niu, Xizhen1; Zhang, Hong1
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2011-02-11 |
| 卷号 | 84期号:1页码:417-423 |
| 关键词 | Fucoidan Ckd Adenine Antioxidant |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2010.11.055 |
| 文献子类 | Article |
| 英文摘要 | In the present study, the beneficial effects of two sulfated polysaccharides DF and UF on adenine-induced chronic kidney disease (CKD) were investigated. Compare the chemical composition of DF and UF, DF had more sulfated group than OF, however, UF had more uronic acid. The results showed OF and OF had significant protective role in deleting the peroxidative and renal damage in CKD rats. Both samples exhibited nearly the same effect on the SUN and SCR level, however, OF showed greater effect on activity/level of CAT, GSH-PX, GSH and MDA in serum and liver compared to UF. That was to say the sample with higher content of sulfate group exhibited greater antioxidant activity. There was a positive correlation between MDA level and renal membrane damage indicating a striking relation between free radical formation and cellular injury. The mechanism of OF and OF on the CKD rats had relationship with their antioxidant activities, the samples which could enhance the activity of antioxidant enzymes and reduce the LPO level could alleviate the symptom of CKD complications. (C) 2010 Elsevier Ltd. All rights reserved.; In the present study, the beneficial effects of two sulfated polysaccharides DF and UF on adenine-induced chronic kidney disease (CKD) were investigated. Compare the chemical composition of DF and UF, DF had more sulfated group than OF, however, UF had more uronic acid. The results showed OF and OF had significant protective role in deleting the peroxidative and renal damage in CKD rats. Both samples exhibited nearly the same effect on the SUN and SCR level, however, OF showed greater effect on activity/level of CAT, GSH-PX, GSH and MDA in serum and liver compared to UF. That was to say the sample with higher content of sulfate group exhibited greater antioxidant activity. There was a positive correlation between MDA level and renal membrane damage indicating a striking relation between free radical formation and cellular injury. The mechanism of OF and OF on the CKD rats had relationship with their antioxidant activities, the samples which could enhance the activity of antioxidant enzymes and reduce the LPO level could alleviate the symptom of CKD complications. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry ; Polymer Science |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000287349500055 |
| 公开日期 | 2012-07-03 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/12010]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Zhang, Quanbin,Jin, Weihua,et al. Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine[J]. CARBOHYDRATE POLYMERS,2011,84(1):417-423. |
| APA | Wang, Jing,Zhang, Quanbin,Jin, Weihua,Niu, Xizhen,&Zhang, Hong.(2011).Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine.CARBOHYDRATE POLYMERS,84(1),417-423. |
| MLA | Wang, Jing,et al."Effects and mechanism of low molecular weight fucoidan in mitigating the peroxidative and renal damage induced by adenine".CARBOHYDRATE POLYMERS 84.1(2011):417-423. |
入库方式： OAI收割
来源：海洋研究所
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