Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides
文献类型：期刊论文
| 作者 | Zhao, JL ; Ma, M; Wang, SJ; Li, S; Cao, P; Yang, YC; Lu, Y; Shi, JG; Xu, NJ; Fan, X
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2005-05-01 |
| 卷号 | 68期号:5页码:691-694 |
| 关键词 | Polysiphonia-urceolata Odonthalia Corymbifera Leathesia-nana Larix |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np040234m |
| 文献子类 | Article |
| 英文摘要 | Three new bromophenols coupled with pyroglutamic acid derivatives and one bromophenol coupled with deoxyguanosine were obtained from the red alga Rhodomela confervoides. By spectroscopic methods including 2D NMR and single-crystal X-ray structure analysis their structures were elucidated as N-(2,3-dibromo-4,5-dihydroxybenzyl)methyl pyroglutamate (1), N-(2,3-dibromo-4,5-dihydroxybenzyl)pyroglutamic acid (2), N-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyllmethyl pyroglutamate (3), and 2-N-(2,3-dibromo-4,5-dihydroxybenzylamino)deoxyguanosine (4), respectively. Compounds 1-4 were evaluated against several microorganisms and human cancer cell lines, but found inactive. To our knowledge this is the first report of bromophenols coupled with amino acid or nucleoside derivatives through the C-N bond.; Three new bromophenols coupled with pyroglutamic acid derivatives and one bromophenol coupled with deoxyguanosine were obtained from the red alga Rhodomela confervoides. By spectroscopic methods including 2D NMR and single-crystal X-ray structure analysis their structures were elucidated as N-(2,3-dibromo-4,5-dihydroxybenzyl)methyl pyroglutamate (1), N-(2,3-dibromo-4,5-dihydroxybenzyl)pyroglutamic acid (2), N-[3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyllmethyl pyroglutamate (3), and 2-N-(2,3-dibromo-4,5-dihydroxybenzylamino)deoxyguanosine (4), respectively. Compounds 1-4 were evaluated against several microorganisms and human cancer cell lines, but found inactive. To our knowledge this is the first report of bromophenols coupled with amino acid or nucleoside derivatives through the C-N bond. |
| 学科主题 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000229596900010 |
| 公开日期 | 2010-11-18 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/1891]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 通讯作者 | Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, JL,Ma, M,Wang, SJ,et al. Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(5):691-694. |
| APA | Zhao, JL.,Ma, M.,Wang, SJ.,Li, S.,Cao, P.,...&Shi, JG, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China.(2005).Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.JOURNAL OF NATURAL PRODUCTS,68(5),691-694. |
| MLA | Zhao, JL,et al."Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides".JOURNAL OF NATURAL PRODUCTS 68.5(2005):691-694. |
入库方式： OAI收割
来源：海洋研究所
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