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Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro

文献类型：期刊论文

作者Xing, RE; Liu, S; Guo, ZY; Yu, HH; Wang, PB; Li, CP; Li, Z; Li, PC
刊名BIOORGANIC & MEDICINAL CHEMISTRY
出版日期2005-03-01
卷号13期号:5页码:1573-1577
关键词Dmw Chitosans Dmw Sulfated Chitosans Radical Scavenging Effect Reducing Power Chelating Effect Comparative Relevance
ISSN号0968-0896
DOI10.1016/j.bmc.2004.12.022
文献子类Article
英文摘要The antioxidant potency of different molecular weight (DMW) chitosan and sulfated chitosan derivatives was investigated employing various established in vitro systems, such as superoxide (O(2)(.-))/hydroxyl ((.)OH) radicals scavenging, reducing power, iron ion chelating. As expected, we obtained several satisfying results, as follows:; The antioxidant potency of different molecular weight (DMW) chitosan and sulfated chitosan derivatives was investigated employing various established in vitro systems, such as superoxide (O-2(.-))/hydroxyl ((OH)-O-.) radicals scavenging, reducing power, iron ion chelating. As expected, we obtained several satisfying results, as follows: Firstly, low molecular weight chitosan had stronger scavenging effect on O-2(.-) and (OH)-O-. than high molecular weight chitosan. For example the O-2(.-) scavenging activity of low molecular weight chitosan (9 kDa) and high molecular weight chitosan (760 kDa) were 85.86 % and 35.50 % at 1.6 mg/mL, respectively. Secondly, comparing with DMW chitosan, DMW sulfated chitosans had the stronger inhibition effect on 0(2)(.-). At 0.05 mg/mL, the scavenging activity on O-2(.-) reached 86.26 %, for low molecular weight chitosan sulfate (9 kDa), but that of low molecular weight chitosan (9 kDa) was 85.86 % at 1.6 mg/mL. As concerning chitosan and sulfated chitosan of the same molecular weight, scavenging activities of sulfated chitosan on superoxide and hydroxyl radicals were more pronounced than that of chitosan. Thirdly, low molecular weight chitosan sulfate had more effective scavenging activity on 02 and (OH)-O-. than that of high molecular weight chitosan sulfate. Fourthly, DMW chitosans and sulfated chitosans were efficient in the reducing power, especially LCTS. Their orders were found to be LCTS > CTS4 > HCTS > CTS3 > CTS2 > CTS1 > CTS. Fifthly, CTS4 showed more considerable ferrous ion-chelating potency than others. Finally, the scavenging rate and reducing power of DMW chitosan and sulfated derivatives increased with their increasing concentration. Moreover, change of DMW sulfated chitosans was the most pronounced within the experimental concentration. However, chelating effect of DMW chitosans were not concentration dependent except for CTS4 and CTS1. (C) 2004 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
URL标识查看原文
语种英语
WOS记录号WOS:000227251300016
公开日期2010-12-22
源URL[http://ir.qdio.ac.cn/handle/337002/3545]  
专题海洋研究所_海洋生物技术研发中心
海洋研究所_海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Xing, RE,Liu, S,Guo, ZY,et al. Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2005,13(5):1573-1577.
APA Xing, RE.,Liu, S.,Guo, ZY.,Yu, HH.,Wang, PB.,...&Li, PC.(2005).Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro.BIOORGANIC & MEDICINAL CHEMISTRY,13(5),1573-1577.
MLA Xing, RE,et al."Relevance of molecular weight of chitosan and its derivatives and their antioxidant activities in vitro".BIOORGANIC & MEDICINAL CHEMISTRY 13.5(2005):1573-1577.

入库方式： OAI收割

来源：海洋研究所

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