Fucoidan inhibits the development of proteinuria in active Heymann nephritis
文献类型：期刊论文
| 作者 | Zhang, QB; Li, N; Zhao, TT; Qi, HM; Xu, ZH; Li, Z
|
| 刊名 | PHYTOTHERAPY RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 19期号:1页码:50-53 |
| 关键词 | Fucoidan Laminaria Japonica Laminariales Proteinuria Heymann Nephritis |
| ISSN号 | 0951-418X |
| DOI | 10.1002/ptr.1623 |
| 文献子类 | Article |
| 英文摘要 | Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright (c) 2005 John Wiley F Sons, Ltd.; Fucoidan, the sulphated polysaccharide extracted from brown seaweed, has various biological activities. The effect of fucoidan on the formation of proteinuria and renal functions in active Heymann nephritis was investigated in this study. Active Heymann nephritis was induced by administering brush border protein of rat proximal uriniferous tubules (FX1A). Fucoidan was administered by oral intubation to Heymann nephritis rats at three doses (50, 100 and 200 mg/kg) once daily for 4 weeks. The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan at doses of 100 and 200 mg/kg. The results indicated that fucoidan has a renoprotective effect on active Heymann nephritis and is a promising therapeutic agent for nephritis. Copyright (c) 2005 John Wiley F Sons, Ltd. |
| 学科主题 | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000228049900007 |
| 公开日期 | 2010-12-22 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/3559]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, QB,Li, N,Zhao, TT,et al. Fucoidan inhibits the development of proteinuria in active Heymann nephritis[J]. PHYTOTHERAPY RESEARCH,2005,19(1):50-53. |
| APA | Zhang, QB,Li, N,Zhao, TT,Qi, HM,Xu, ZH,&Li, Z.(2005).Fucoidan inhibits the development of proteinuria in active Heymann nephritis.PHYTOTHERAPY RESEARCH,19(1),50-53. |
| MLA | Zhang, QB,et al."Fucoidan inhibits the development of proteinuria in active Heymann nephritis".PHYTOTHERAPY RESEARCH 19.1(2005):50-53. |
入库方式： OAI收割
来源：海洋研究所
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