Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis
文献类型：期刊论文
| 作者 | Zhao, Tingting1,2; Zhang, Quanbin1; Qi, Huimin3; Liu, Xiguang4; Li, Zhien1 |
| 刊名 | PHARMACOLOGICAL RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 57期号:1页码:67-72 |
| 关键词 | Drosophila Melanogaster Porphyrans Life Span Heat Stress Mating Capacity |
| ISSN号 | 1043-6618 |
| DOI | 10.1016/j.phrs.2007.12.001 |
| 文献子类 | Article |
| 英文摘要 | Polysaccharides isolated from Porphyra (porphyran) have been known to have diverse biological activities, including immunomodulatory and antioxidant activities. The molecular weight-antiaging activity relationship of degraded porphyrans was examined in this study. Natural porphyran was extracted from P. haitanensis, and then was degraded into different molecular weight fractions, P1 molecular weight 49 kDa, P2 molecular weight 30 kDa, P3 molecular weight 8.2 kDa, by free radical. The influence on life span and vitality of porphyrans were carried out on Drosophila melanogaster. We found that all the degraded porphyrans and natural porphyran (P), added daily to the diet, can significantly increase the life span of D. melanogaster, except for P3. Among them, P1 exhibited the most prolonging life span activity. Furthermore, vitality of middle-aged flies (assessed by measuring their mating capacity) receiving porphyrans was increased considerably in comparison with the controls. Finally, in the heat-stress test, we observed a remarkable increase in survival time, especially in P3-diet groups. These results suggest that porphyrans may be effective in reducing the rate of the aging process and molecular weight has important influence on the effects. It seems that P1 and P2, possessed higher molecular weight, may be more useful in normal metabolic condition and P3, possessed the lowest molecular weight, may be more beneficial for D. melanogaster in stress condition. (C) 2007 Elsevier Ltd. All rights reserved.; Polysaccharides isolated from Porphyra (porphyran) have been known to have diverse biological activities, including immunomodulatory and antioxidant activities. The molecular weight-antiaging activity relationship of degraded porphyrans was examined in this study. Natural porphyran was extracted from P. haitanensis, and then was degraded into different molecular weight fractions, P1 molecular weight 49 kDa, P2 molecular weight 30 kDa, P3 molecular weight 8.2 kDa, by free radical. The influence on life span and vitality of porphyrans were carried out on Drosophila melanogaster. We found that all the degraded porphyrans and natural porphyran (P), added daily to the diet, can significantly increase the life span of D. melanogaster, except for P3. Among them, P1 exhibited the most prolonging life span activity. Furthermore, vitality of middle-aged flies (assessed by measuring their mating capacity) receiving porphyrans was increased considerably in comparison with the controls. Finally, in the heat-stress test, we observed a remarkable increase in survival time, especially in P3-diet groups. These results suggest that porphyrans may be effective in reducing the rate of the aging process and molecular weight has important influence on the effects. It seems that P1 and P2, possessed higher molecular weight, may be more useful in normal metabolic condition and P3, possessed the lowest molecular weight, may be more beneficial for D. melanogaster in stress condition. (C) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000254035100010 |
| 公开日期 | 2010-12-24 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/6123]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.China Japan Friendship Hosp, Inst Clin Res, Beijing 100029, Peoples R China 3.Weifang Med Univ, Weifang 261042, Peoples R China 4.Laiyang Agr Coll, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Tingting,Zhang, Quanbin,Qi, Huimin,et al. Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis[J]. PHARMACOLOGICAL RESEARCH,2008,57(1):67-72. |
| APA | Zhao, Tingting,Zhang, Quanbin,Qi, Huimin,Liu, Xiguang,&Li, Zhien.(2008).Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis.PHARMACOLOGICAL RESEARCH,57(1),67-72. |
| MLA | Zhao, Tingting,et al."Extension of life span and improvement of vitality of Drosophila melanogaster by long-term supplementation with different molecular weight polysaccharides from Porphyra haitanensis".PHARMACOLOGICAL RESEARCH 57.1(2008):67-72. |
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来源：海洋研究所
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