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The antioxidant activity of glucosamine hydrochloride in vitro

文献类型：期刊论文

作者Xing, RE; Liu, S; Guo, ZY; Yu, HH; Li, CP; Ji, X; Feng, JH; Li, PC
刊名BIOORGANIC & MEDICINAL CHEMISTRY
出版日期2006-03-15
卷号14期号:6页码:1706-1709
关键词Glucosamine Hydrochloride Radical Scavenging Effect Reducing Power Clelating Effect
ISSN号0968-0896
DOI10.1016/j.bmc.2005.10.018
文献子类Article
英文摘要The antioxidant potency of chitin derivative-glucosamine hydrochloride was investigated employing various established in vitro systems. Such as superoxide (O(2)(center dot-))/hydroxyl ((center dot)OH)-radical scavenging, reducing power, and ferrous ion chelating potency. As expected, we obtained several satisfying results, its follows: first, glucosamine hydrochloride had pronounced scavenging effect on superoxide radical. For example, the O(2)(center dot-) scavenging activity of glucosamine hydrochloride was 83.74 parts per thousand at 0.8 mg/mL. Second, the (center dot)OH scavenging activity of glucosamine hydrochloride was also strong and was about 54.89% at 3.2 mg/mL. Third, the reducing power of glucosamine hydrochloride was more pronounced. The reducing power of glucosamine hydrochloride was 0.632 at 0.75 mg/mL. However, ferrous ion-chelating potency was soft. Furthermore, ferrous ion-chelating potency, the scavenging rate of radical, and the reducing power of glucosamine hydrochloride increased with their increasing concentration, and they were concentration dependent. The multiple antioxidant activity of glucosamine hydrochloride was evident as it showed considerable reducing power, superoxide/hydroxyl-radical scavenging ability. These in vitro results suggest the possibility that glucosamille hydrochloride could be effectively employed its an ingredient in health or functional food, to alleviate oxidative stress. (c) 2005 Elsevier Ltd. All rights reserved.; The antioxidant potency of chitin derivative-glucosamine hydrochloride was investigated employing various established in vitro systems. Such as superoxide (O-2(center dot-))/hydroxyl ((OH)-O-center dot)-radical scavenging, reducing power, and ferrous ion chelating potency. As expected, we obtained several satisfying results, its follows: first, glucosamine hydrochloride had pronounced scavenging effect on superoxide radical. For example, the O-2(center dot-) scavenging activity of glucosamine hydrochloride was 83.74 parts per thousand at 0.8 mg/mL. Second, the (OH)-O-center dot scavenging activity of glucosamine hydrochloride was also strong and was about 54.89% at 3.2 mg/mL. Third, the reducing power of glucosamine hydrochloride was more pronounced. The reducing power of glucosamine hydrochloride was 0.632 at 0.75 mg/mL. However, ferrous ion-chelating potency was soft. Furthermore, ferrous ion-chelating potency, the scavenging rate of radical, and the reducing power of glucosamine hydrochloride increased with their increasing concentration, and they were concentration dependent. The multiple antioxidant activity of glucosamine hydrochloride was evident as it showed considerable reducing power, superoxide/hydroxyl-radical scavenging ability. These in vitro results suggest the possibility that glucosamille hydrochloride could be effectively employed its an ingredient in health or functional food, to alleviate oxidative stress. (c) 2005 Elsevier Ltd. All rights reserved.
学科主题Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
URL标识查看原文
语种英语
WOS记录号WOS:000235579900003
公开日期2010-12-24
源URL[http://ir.qdio.ac.cn/handle/337002/6167]  
专题海洋研究所_海洋生物技术研发中心
海洋研究所_海洋环境工程技术研究发展中心
作者单位1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714		 Xing, RE,Liu, S,Guo, ZY,et al. The antioxidant activity of glucosamine hydrochloride in vitro[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2006,14(6):1706-1709.
APA Xing, RE.,Liu, S.,Guo, ZY.,Yu, HH.,Li, CP.,...&Li, PC.(2006).The antioxidant activity of glucosamine hydrochloride in vitro.BIOORGANIC & MEDICINAL CHEMISTRY,14(6),1706-1709.
MLA Xing, RE,et al."The antioxidant activity of glucosamine hydrochloride in vitro".BIOORGANIC & MEDICINAL CHEMISTRY 14.6(2006):1706-1709.

入库方式： OAI收割

来源：海洋研究所

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