中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Study on the retention equation in hydrophilic interaction liquid chromatography

文献类型:期刊论文

作者Jin, Gaowa; Guo, Zhimou; Zhang, Feifang; Xue, Xingya; Jin, Yu; Liang, Xinmiao
刊名talanta
出版日期2008-07-30
卷号76期号:3页码:522-527
关键词hydrophilic interaction liquid chromatography retention equation stationary phases selectivity nucleoside
产权排序1;1
通讯作者梁鑫淼
英文摘要hydrophilic interaction liquid chromatography (hilic) is an effective technique for separating polar compounds. but its retention equation has not been studied systematically yet. in this study, an appropriate retention equation was established by using eight nucleosides as model analytes and by comparing four retention models on six different hilic columns. as a result, retention equation in k = a + b x incb + c x c-b could be quantitatively described the retention factors with good accuracy in hilic mode. based on this equation, the retention times of eight nucleosides under the conditions by other mobile phase can be predicted on each column. all of the predicted relative errors of retention times were smaller than 5%. the established retention model was also successfully applied to predict retention times of the real traditional chinese medicine-carthaus tinctorius l. sample. (c) 2008 elsevier b.v. all rights reserved.
WOS标题词science & technology ; physical sciences
类目[WOS]chemistry, analytical
研究领域[WOS]chemistry
关键词[WOS]electrospray mass-spectrometry ; light-scattering detection ; small polar compounds ; reversed-phase ; adrenoreceptor agonists ; stationary-phase ; drug discovery ; separation ; silica ; performance
收录类别SCI
原文出处true
语种英语
WOS记录号WOS:000257577100006
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/100097]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
Jin, Gaowa,Guo, Zhimou,Zhang, Feifang,et al. Study on the retention equation in hydrophilic interaction liquid chromatography[J]. talanta,2008,76(3):522-527.
APA Jin, Gaowa,Guo, Zhimou,Zhang, Feifang,Xue, Xingya,Jin, Yu,&Liang, Xinmiao.(2008).Study on the retention equation in hydrophilic interaction liquid chromatography.talanta,76(3),522-527.
MLA Jin, Gaowa,et al."Study on the retention equation in hydrophilic interaction liquid chromatography".talanta 76.3(2008):522-527.

入库方式: OAI收割

来源:大连化学物理研究所

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