Long noncoding rna (incrna) small nucleolar rna host gene 16 (snhg16) predicts poor prognosis and sorafenib resistance in hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Guo, Zhenli1,2; Zhang, Ju1,3; Fan, Lulu1; Liu, Jiatao1; Yu, Hanging1; Li, Xiaoqiu1; Sun, Guoping1 |
| 刊名 | Medical science monitor
 |
| 出版日期 | 2019-03-20 |
| 卷号 | 25页码:2079-2086 |
| 关键词 | Carcinoma, hepatocellular Prognosis Rna, long noncoding |
| ISSN号 | 1643-3750 |
| DOI | 10.12659/msm.915541 |
| 通讯作者 | Sun, guoping(sungp@ahmu.edu.cn) |
| 英文摘要 | Background: long noncoding rnas (incrnas) play important roles in cancer development and therapeutic resistance. however, the role of small nucleolar rna host gene 16 (snhg16) in the development of hepatocellular carcinoma (hcc) remains largely unknown. material/methods: in situ hybridization (ish) staining was performed to detect the expression level of snhg16 in hcc tissues and adjacent non-cancerous tissues. quantitative real-time polymerase chain reaction (qrt-pcr) was used to detect the level of snhg16 in hcc samples, adjacent non-cancerous tissues and hcc cell lines. transwell assay was performed to investigate the migration and invasion ability of hcc cells. cell viability assays were performed to determine the ability of proliferation and sorafenib resistance of hcc cells. results: we found that snhg16 was upregulated in hcc tissues and cell lines and that it was negatively correlated with survival time in hcc patients. univariate and multivariate analyses revealed that snhg16 was a significant and independent predictor for the overall survival of hcc patients. furthermore, downregulation of snhg16 inhibited proliferation, migration, invasion, and sorafenib resistance in hepatocellular carcinoma cell lines. conclusions: our findings revealed that incrna snhg16 could be used as an oncogene to predict the outcome of hepato-cellular carcinoma. |
| WOS关键词 | CANCER ; SURVEILLANCE ; CHROMATIN ; CATENIN |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000463273900003 |
| 出版者 | INT SCIENTIFIC INFORMATION, INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372624 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Sun, Guoping |
| 作者单位 | 1.Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei, Anhui, Peoples R China 2.Univ Sci & Technol China, Affiliated Hosp 1, Dept Pathol, Hefei, Anhui, Peoples R China 3.Univ Sci & Technol China, Affiliated Hosp 1, Dept Lab Med, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Zhenli,Zhang, Ju,Fan, Lulu,et al. Long noncoding rna (incrna) small nucleolar rna host gene 16 (snhg16) predicts poor prognosis and sorafenib resistance in hepatocellular carcinoma[J]. Medical science monitor,2019,25:2079-2086. |
| APA | Guo, Zhenli.,Zhang, Ju.,Fan, Lulu.,Liu, Jiatao.,Yu, Hanging.,...&Sun, Guoping.(2019).Long noncoding rna (incrna) small nucleolar rna host gene 16 (snhg16) predicts poor prognosis and sorafenib resistance in hepatocellular carcinoma.Medical science monitor,25,2079-2086. |
| MLA | Guo, Zhenli,et al."Long noncoding rna (incrna) small nucleolar rna host gene 16 (snhg16) predicts poor prognosis and sorafenib resistance in hepatocellular carcinoma".Medical science monitor 25(2019):2079-2086. |
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来源：大连化学物理研究所
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