Characterization of tropane and cinnamamide alkaloids from scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry
文献类型：期刊论文
| 作者 | Du, Nana1,2; Zhou, Weijia1,2; Jin, Hongli1; Liu, Yanfang1; Zhou, Han1; Liang, Xinmiao1 |
| 刊名 | Journal of separation science
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 42期号:6页码:1163-1173 |
| 关键词 | Cinnamamide Quadrupole time-of-flight tandem mass spectrometry Scopolia tangutica Tropane alkaloids |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.201801201 |
| 通讯作者 | Liu, yanfang(liuyanfang@dicp.ac.cn) ; Liang, xinmiao(liangxm@dicp.ac.cn) |
| 英文摘要 | Scopolia tangutica is a traditional chinese medicine used for antispasmodic, anesthesia, analgesia, and sedation. its medicinal activity is associated to alkaloid constituents, including tropane and cinnamamide types. low content of alkaloids in plant makes them difficult to be isolated and identified. the present work developed an effective method to quickly characterize alkaloids from scopolia tangutica by highperformance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. thirteen reference compounds were studied for their fragmentation pathways, including five tropane alkaloids and eight cinnamamide ones. alkaloid constituent was analyzed by an optimized high-performance liquid chromatography method and mass spectrometry analysis to achieve systematic characterization of alkaloids fromscopolia tangutica. as a result, 53 compoundswere identified, including 21 tropane alkaloids (eight new ones), 18 caffeoyl ones (ten new ones) and 14 dicaffeoyl ones (seven new ones). it was important to provide rich information in phytochemical study and structure-guided isolation of important compounds from this plant. |
| WOS关键词 | QUANTITATIVE-ANALYSIS ; PANCREATIC-SECRETION ; RAT URINE ; METABOLITES ; SCOPOLAMINE ; ATROPINE ; AMIDES ; L. ; PURIFICATION ; ANISODAMINE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000462257700005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372653 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Liu, Yanfang; Liang, Xinmiao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Nana,Zhou, Weijia,Jin, Hongli,et al. Characterization of tropane and cinnamamide alkaloids from scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry[J]. Journal of separation science,2019,42(6):1163-1173. |
| APA | Du, Nana,Zhou, Weijia,Jin, Hongli,Liu, Yanfang,Zhou, Han,&Liang, Xinmiao.(2019).Characterization of tropane and cinnamamide alkaloids from scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.Journal of separation science,42(6),1163-1173. |
| MLA | Du, Nana,et al."Characterization of tropane and cinnamamide alkaloids from scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry".Journal of separation science 42.6(2019):1163-1173. |
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来源：大连化学物理研究所
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