Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial
文献类型：期刊论文
| 作者 | Zhang, Lei1,2,3; Ouyang, Yang4,5; Li, Huating1,2; Shen, Li6; Ni, Yueqiong7,8,9; Fang, Qichen1,2; Wu, Guangyu1,2,3; Qian, Lingling1,2,3; Xiao, Yunfeng; Zhang, Jing1,2,3 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2019-03-20 |
| 卷号 | 9页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-38216-9 |
| 通讯作者 | Li, huating(huarting99@sjtu.edu.cn) ; Xu, guowang(xugw@dicp.ac.cn) ; Jia, weiping(wpjia@sjtu.edu.cn) |
| 英文摘要 | Resistant starch (rs) has been reported to reduce body fat in obese mice. however, this effect has not been demonstrated in humans. in this study, we tested the effects of rs in 19 volunteers with normal body weights. a randomized, double-blinded and crossover design clinical trial was conducted. the study subjects were given either 40 g high amylose rs2 or energy-matched control starch with three identical diets per day throughout the study. the effect of rs was evaluated by monitoring body fat, glucose metabolism, gut hormones, gut microbiota, short-chain fatty acids (scfas) and metabolites. the visceral and subcutaneous fat areas were significantly reduced following rs intake. acetate and early-phase insulin, c-peptide and glucagon-like peptide-1 (glp-1) secretion were increased, and the low-density lipoprotein cholesterol (ldl-c) and blood urea nitrogen (bun) levels were decreased after the rs intervention. based on 16s rrna sequencing, certain gut microbes were significantly decreased after rs supplementation, whereas the genus ruminococcaceae_ucg-005 showed an increase in abundance. other potential signatures of the rs intervention included akkermansia, ruminococcus_2, victivallis, and comamonas. moreover, the baseline abundance of the genera streptococcus, ruminococcus_torques_group, eubacterium_hallii_group, and eubacterium_eligens_group was significantly associated with the hormonal and metabolic effects of rs. these observations suggest that a daily intake of 40 g of rs is effective in modulating body fat, scfas, early-phase insulin and glp-1 secretion and the gut microbiota in normal-weight subjects. |
| WOS关键词 | CHAIN FATTY-ACIDS ; ADIPOSE-TISSUE ; INSULIN SENSITIVITY ; GLYCEMIC INDEX ; GLUCOSE ; EXPRESSION ; AMYLOSE ; GLP-1 ; CHOLESTEROL ; CONSUMPTION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000461761200001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372673 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Li, Huating; Xu, Guowang; Jia, Weiping |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China 2.Shanghai Clin Ctr Diabet, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Dept Med, Shanghai 200025, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Clin Nutr, Shanghai 200233, Peoples R China 7.HKI, Leibniz Inst Nat Prod Res & Infect Biol, Dept Syst Biol & Bioinformat, Beutenbergstr 11a, D-07745 Jena, Germany 8.Univ Hong Kong, Sch Biol Sci, Syst Biol & Bioinformat Grp, Hong Kong, Peoples R China 9.Univ Hong Kong, Dept Microbiol, Hong Kong, Peoples R China 10.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Radiol, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Ouyang, Yang,Li, Huating,et al. Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial[J]. Scientific reports,2019,9:11. |
| APA | Zhang, Lei.,Ouyang, Yang.,Li, Huating.,Shen, Li.,Ni, Yueqiong.,...&Jia, Weiping.(2019).Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial.Scientific reports,9,11. |
| MLA | Zhang, Lei,et al."Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial".Scientific reports 9(2019):11. |
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来源：大连化学物理研究所
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