Quantification of bisphenol a and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry
文献类型：期刊论文
| 作者 | Tan, Dongqin1,2; Jin, Jing1; Wang, Longxing1; He, Xiaolin3; Guo, Cuicui1,2; Dhanjai1; Lu, Xianbo1; Chen, Jiping1 |
| 刊名 | Journal of separation science
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 42期号:5页码:991-998 |
| ISSN号 | 1615-9306 |
| 关键词 | Bisphenol Derivatization High-performance liquid chromatography Serum tandem mass spectrometry |
| DOI | 10.1002/jssc.201800847 |
| 通讯作者 | Chen, jiping(chenjp@dicp.ac.cn) |
| 英文摘要 | Due to regulation of the use of bisphenol a, several analogs serving as bisphenol a replacements have drawn substantial attention for their adverse health effects. to investigate their occurrence in humans and identify possible pollution sources, it is necessary to develop a sensitive method for total bisphenols detection. thus, a method based on enzymolysis and liquid-liquid extraction followed by molecularly imprinted polymer solid-phase extraction and pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry was proposed. the developed method exhibited superior selectivity and sensitivity. the matrix effect can be eliminated to a great extent. the method detection limits for eight bisphenols were 0.05 similar to 0.19 ng/ml. satisfactory recoveries (71 similar to 119%) were obtained by spiking bovine serum at three levels (0.8, 8 and, 20 ng/ml). the method was successfully applied to determine total bisphenols in the serum samples of children. bisphenol a, bisphenol f, bisphenol s, bisphenol b and bisphenol f were detected with concentrations from below the method detection limit to 1.65, 0.45, 0.79, 2.04 and 0.17 ng/ml, respectively. these results indicate that bisphenol a remains the major pollutant among the studied bisphenols in children, whereas threats from bisphenol a analogs should also be monitored. |
| WOS关键词 | ENDOCRINE DISRUPTING CHEMICALS ; HUMAN PLASMA ; HUMAN URINE ; EXPOSURE ; CHLORIDE ; BLOOD ; MILK |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000461674900004 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372727 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Chen, Jiping |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Dalian Med Univ, Hosp 2, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Dongqin,Jin, Jing,Wang, Longxing,et al. Quantification of bisphenol a and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry[J]. Journal of separation science,2019,42(5):991-998. |
| APA | Tan, Dongqin.,Jin, Jing.,Wang, Longxing.,He, Xiaolin.,Guo, Cuicui.,...&Chen, Jiping.(2019).Quantification of bisphenol a and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry.Journal of separation science,42(5),991-998. |
| MLA | Tan, Dongqin,et al."Quantification of bisphenol a and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry".Journal of separation science 42.5(2019):991-998. |
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来源：大连化学物理研究所
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