Catalytic biomimetic asymmetric reduction of alkenes and imines enabled by chiral and regenerable nad(p)h models
文献类型：期刊论文
| 作者 | Wang, Jie1,2; Zhu, Zhou-Hao1; Chen, Mu-Wang1; Chen, Qing-An1; Zhou, Yong-Gui1,3 |
| 刊名 | Angewandte chemie-international edition
 |
| 出版日期 | 2019-02-04 |
| 卷号 | 58期号:6页码:1813-1817 |
| 关键词 | Alkenes Asymmetric synthesis Biomimetic chemistry Reduction Synthetic methods |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201813400 |
| 通讯作者 | Zhou, yong-gui(ygzhou@dicp.ac.cn) |
| 英文摘要 | The development of biomimetic chemistry based on the nad(p)h with hydrogen gas as terminal reductant is a long-standing challenge. through rational design of the chiral and regenerable nad(p)h analogues based on planarchiral ferrocene, a biomimetic asymmetric reduction has been realized using bench-stable lewis acids as transfer catalysts. a broad set of alkenes and imines could be reduced with up to 98% yield and 98% ee, likely enabled by enzyme-like cooperative bifunctional activation. this reaction represents the first general biomimetic asymmetric reduction (bmar) process enabled by chiral and regenerable nad(p)h analogues. this concept demonstrates catalytic utility of a chiral coenzyme nad(p)h in asymmetric catalysis. |
| WOS关键词 | ORGANOCATALYTIC TRANSFER HYDROGENATION ; HYDROAMINATION/ASYMMETRIC TRANSFER HYDROGENATION ; ENANTIOSELECTIVE TRANSFER HYDROGENATION ; HANTZSCH ESTERS ; METAL-FREE ; NADH ; BENZOTHIAZOLINE ; QUINOLINES ; DEHYDROGENASE ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000458826800048 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372756 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Zhou, Yong-Gui |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Dalian Univ Technol, Zhang Dayu Sch Chem, State Key Lab Fine Chem, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jie,Zhu, Zhou-Hao,Chen, Mu-Wang,et al. Catalytic biomimetic asymmetric reduction of alkenes and imines enabled by chiral and regenerable nad(p)h models[J]. Angewandte chemie-international edition,2019,58(6):1813-1817. |
| APA | Wang, Jie,Zhu, Zhou-Hao,Chen, Mu-Wang,Chen, Qing-An,&Zhou, Yong-Gui.(2019).Catalytic biomimetic asymmetric reduction of alkenes and imines enabled by chiral and regenerable nad(p)h models.Angewandte chemie-international edition,58(6),1813-1817. |
| MLA | Wang, Jie,et al."Catalytic biomimetic asymmetric reduction of alkenes and imines enabled by chiral and regenerable nad(p)h models".Angewandte chemie-international edition 58.6(2019):1813-1817. |
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来源：大连化学物理研究所
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