Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination
文献类型：期刊论文
| 作者 | Wei, Qiuhong1,2; Su, Hongjiu1; Gao, Diannan1; Wang, Shudong1 |
| 刊名 | Chirality
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 31期号:3页码:164-173 |
| ISSN号 | 0899-0042 |
| 关键词 | Cellulose tris (3,5-dimethylphenylcarbamate) Chiral recognition Chiral stationary phase Enantioseparation High-performance liquid chromatography Resolution |
| DOI | 10.1002/chir.23044 |
| 通讯作者 | Su, hongjiu(suhj@dicp.ac.cn) ; Wang, shudong(wangsd@dicp.ac.cn) |
| 英文摘要 | Coating cellulose tris (3,5-dimethylphenylcarbamate) (cdmpc) on silica gels with large pores have been demonstrated as an efficient way for the preparation of chiral stationary phase (csp) for high-performance liquid chromatography (hplc). during the process, a number of parameters, including the type of coating solvent, amount of coating, and the method for subsequent solvent removing, have been proved to affect the performance of the resultant csps. coating times and the concentration of coating solution, however, also makes a difference to csps' performance by changing the arrangement of cellulose derivatives while remaining the coating amount constant, have much less been studied before, and thereby, were systematically investigated in this work. results showed that csps with more coating times exhibited higher chiral recognition and column efficiency, suggesting that resolution was determined by column efficiency herein. afterwards, we also investigated the effect of coating amount on the performance of csps, and it was shown that the ability of enantio-recognition did not increase all the time as the coating amount; and four of seven racemates achieved best resolution when the coating amount reached to 18.37%. at the end, the reproducibility of cdmpc-coated csps were further confirmed by two methods, ie, reprepared the csp-0.15-3 and reevaluated the effect of coating times. |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; SILICA-GEL ; RESOLUTION ; ENANTIOMERS ; SEPARATION ; TRIS(3,5-DIMETHYLPHENYLCARBAMATE) ; ENANTIOSEPARATION ; DERIVATIVES |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Analytical ; Chemistry, Organic ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000458827600002 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372777 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Su, Hongjiu; Wang, Shudong |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, 457 Zhongshan Rd, Dalian 116023, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,et al. Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination[J]. Chirality,2019,31(3):164-173. |
| APA | Wei, Qiuhong,Su, Hongjiu,Gao, Diannan,&Wang, Shudong.(2019).Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination.Chirality,31(3),164-173. |
| MLA | Wei, Qiuhong,et al."Hplc with cellulose tris (3,5-dimethylphenylcarbamate) chiral stationary phase: influence of coating times and coating amount on chiral discrimination".Chirality 31.3(2019):164-173. |
入库方式： iSwitch采集
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。