In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage raw264.7 cells
文献类型：期刊论文
| 作者 | Zhang, Weiyue1; Yan, Jingyu2; Wu, Lehao1; Yu, Yang1; Ye, Richard D.1,3; Zhang, Yan1; Liang, Xinmiao2 |
| 刊名 | Carbohydrate polymers
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 207页码:230-238 |
| 关键词 | Human milk oligosaccharides Immunomodulator Nitric oxide Cytokine Nf-kappa b Mapks |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.11.039 |
| 通讯作者 | Zhang, yan(zhangyan_sjtu@sjtu.edu.cn) ; Liang, xinmiao(liangxm@dicp.ac.cn) |
| 英文摘要 | Human milk plays an important role in the child's immune system. the human milk oligosaccharides (hmos) may affect breast-fed infants both locally and systemically. in the present study, hmos were separated, characterized and investigated for the immunomodulatory effects on raw264.7 macrophages and its underlying molecular mechanisms. our results revealed that hmo-7, one of the neutral hmos fractions can significantly induce the production of nitric oxide (no) and pge2 via up-regulating nitric oxide synthase (inos) and cyclooxygenase 2 (cox-2) expression. additionally, hmo-7 was found to stimulate the release of ros, tnf-alpha and cytokines including il-1 beta, il-2, il-6 and il-10 in raw264.7 macrophages. further study showed that macrophage activated by hmo-7 involved in nuclear factor (nf)-kappa b and mitogen-activated protein kinase (mapk) signaling pathways. our study provides additional evidence that hmos are the functional components in human milk and that hmos may have the potential application in healthcare industry. |
| WOS关键词 | SIGNALING PATHWAYS ; POLYMYXIN-B ; ACTIVATION ; INNATE ; POLYSACCHARIDE ; INFANTS ; MAPK ; ALGINATE |
| WOS研究方向 | Chemistry ; Polymer Science |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000454537500025 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372940 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Zhang, Yan; Liang, Xinmiao |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Weiyue,Yan, Jingyu,Wu, Lehao,et al. In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage raw264.7 cells[J]. Carbohydrate polymers,2019,207:230-238. |
| APA | Zhang, Weiyue.,Yan, Jingyu.,Wu, Lehao.,Yu, Yang.,Ye, Richard D..,...&Liang, Xinmiao.(2019).In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage raw264.7 cells.Carbohydrate polymers,207,230-238. |
| MLA | Zhang, Weiyue,et al."In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage raw264.7 cells".Carbohydrate polymers 207(2019):230-238. |
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来源：大连化学物理研究所
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