Single-cell proteomics for cancer immunotherapy
文献类型：期刊论文
| 作者 | Li, Linmei1; Yan, Shiqiang1; Lin, Bingcheng1; Shi, Qihui2,3,4; Lu, Yao1 |
| 刊名 | Cancer nanotechnology
 |
| 出版日期 | 2018 |
| 卷号 | 139页码:185-207 |
| ISSN号 | 0065-230X |
| DOI | 10.1016/bs.acr.2018.04.006 |
| 通讯作者 | Shi, qihui(qihuishi@fudan.edu.cn) ; Lu, yao(luyao@dicp.ac.cn) |
| 英文摘要 | Cancer immunotherapy fights against cancer by modulating the immune response and is delivering encouraging results in clinical treatments. however, it is challenging to achieve durable response in all cancer patients during treatment due to the diversity and dynamic nature of immune system as well as inter-and intratumor heterogeneity. a comprehensive assessment of system immunity and tumor microenvironment is crucial for effective and safe cancer therapy, which can potentially be resolved by single-cell proteomic analysis. single-cell proteomic technologies enable system-wide profiling of protein levels in a number of single cells within the immune system and tumor microenvironment, and thereby provide direct assessment of the functional state of the immune cells and tumor-immune interaction that could be used to evaluate efficacy of immunotherapy and to improve clinical outcome. in this chapter, we summarized current single-cell proteomic technologies and their applications in cancer immunotherapy. |
| WOS关键词 | MULTIPLEXED PROTEIN-ANALYSIS ; FLOW-CYTOMETRY ; MASS CYTOMETRY ; T-CELLS ; CYTOKINE SECRETION ; RESPONSES ; ANTIBODY ; REVEALS ; HETEROGENEITY ; LYMPHOMA |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000453659500009 |
| 出版者 | ELSEVIER ACADEMIC PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2372967 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Shi, Qihui; Lu, Yao |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China 2.Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai, Peoples R China 3.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China 4.Fudan Univ, Minhang Hosp, Inst Fudan Minhang Acad Hlth Syst, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,et al. Single-cell proteomics for cancer immunotherapy[J]. Cancer nanotechnology,2018,139:185-207. |
| APA | Li, Linmei,Yan, Shiqiang,Lin, Bingcheng,Shi, Qihui,&Lu, Yao.(2018).Single-cell proteomics for cancer immunotherapy.Cancer nanotechnology,139,185-207. |
| MLA | Li, Linmei,et al."Single-cell proteomics for cancer immunotherapy".Cancer nanotechnology 139(2018):185-207. |
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来源：大连化学物理研究所
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