Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells
文献类型：期刊论文
| 作者 | Wang, Limeng1,2,3; Li, Xiang1; Yang, Zhihua4; Zhu, Maoxiang4; Xie, Jianping1 |
| 刊名 | Ecotoxicology and environmental safety
 |
| 出版日期 | 2019-01-15 |
| 卷号 | 167页码:169-177 |
| 关键词 | Crotonaldehyde Autophagy Apoptosis Necrosis Programmed cell deaths |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2018.10.008 |
| 通讯作者 | Li, xiang(lixiang79ben@sina.com) ; Xie, jianping(ztridicp@126.com) |
| 英文摘要 | Crotonaldehyde is a common environmental contaminant. autophagy, apoptosis, and necrosis, were all respectively reported to be induced by crotonaldehyde. however, the relationships between programmed cell deaths, especially between autophagy and apoptosis, have not been elucidated. in the present study, alterations of autophagy, apoptosis and necrosis were investigated in human bronchial epithelial cells (beas-2b) exposed to crotonaldehyde, and effects of autophagy on apoptosis and necrosis were detected. we found that a high con- centration (160 mu mol/l mu m) of crotonaldehyde did not induce apoptosis, while a low concentration (80 mu m) of crotonaldehyde induced autophagy, apoptosis and necrosis. in 80 mu m crotonaldehyde-exposed beas-2b cells, autophagy and apoptosis exhibited a trend of increasing prior to decreasing with the increase of time, while the time point inducing the highest level of autophagy was 2 h, and that of apoptosis was 4 h. with the pretreatment of bafilomycin a(1), the apoptosis was inhibited and the necrosis was enhanced significantly in cells exposed to 80 mu m crotonaldehyde. autophagy mediated the induction of apoptosis via the intrinsic apoptotic pathway. the results indicate that autophagy mediates the initiation of apoptosis and plays a role in protecting from necrosis in low concentrations of crotonaldehyde-exposed beas-2b cells. |
| WOS关键词 | ALPHA,BETA-UNSATURATED ALDEHYDES ; CHEMICAL CARCINOGENESIS ; DEPENDENT APOPTOSIS ; DNA-ADDUCTS ; DEOXYGUANOSINE ; IDENTIFICATION ; GENOTOXICITY ; INDUCTION ; RATS ; 1,3-BUTADIENE |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| WOS类目 | Environmental Sciences ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000451360800020 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373029 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Li, Xiang; Xie, Jianping |
| 作者单位 | 1.CNTC, Key Lab Tobacco Chem, Zhengzhou Tobacco Res Inst, 2 Fengyang St, Zhengzhou 450001, Henan, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 4.Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, 27 Taiping Rd, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Limeng,Li, Xiang,Yang, Zhihua,et al. Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells[J]. Ecotoxicology and environmental safety,2019,167:169-177. |
| APA | Wang, Limeng,Li, Xiang,Yang, Zhihua,Zhu, Maoxiang,&Xie, Jianping.(2019).Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells.Ecotoxicology and environmental safety,167,169-177. |
| MLA | Wang, Limeng,et al."Autophagy induced by low concentrations of crotonaldehyde promotes apoptosis and inhibits necrosis in human bronchial epithelial cells".Ecotoxicology and environmental safety 167(2019):169-177. |
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来源：大连化学物理研究所
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