Blood-derived amyloid-beta protein induces alzheimer's disease pathologies
文献类型：期刊论文
| 作者 | Bu, X-L1,2; Xiang, Y.1,2; Jin, W-S1,2; Wang, J.1,2; Shen, L-L1,2; Huang, Z-L3,4; Zhang, K.5,6; Liu, Y-H1,2; Zeng, F.1,2; Liu, J-H7,8 |
| 刊名 | Molecular psychiatry
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 23期号:9页码:9 |
| ISSN号 | 1359-4184 |
| DOI | 10.1038/mp.2017.204 |
| 通讯作者 | Song, w.(weihong@mail.ubc.ca) ; Wang, y-j(yanjiang_wang@tmmu.edu.cn) |
| 英文摘要 | The amyloid-beta protein (a beta) protein plays a pivotal role in the pathogenesis of alzheimer's disease (ad). it is believed that a beta deposited in the brain originates from the brain tissue itself. however, a beta is generated in both brain and peripheral tissues. whether circulating a beta contributes to brain ad-type pathologies remains largely unknown. in this study, using a model of parabiosis between appswe/ps1de9 transgenic ad mice and their wild-type littermates, we observed that the human a beta originated from transgenic ad model mice entered the circulation and accumulated in the brains of wild-type mice, and formed cerebral amyloid angiopathy and a beta plaques after a 12-month period of parabiosis. ad-type pathologies related to the a beta accumulation including tau hyperphosphorylation, neurodegeneration, neuroinflammation and microhemorrhage were found in the brains of the parabiotic wild-type mice. more importantly, hippocampal ca1 long-term potentiation was markedly impaired in parabiotic wild-type mice. to the best of our knowledge, our study is the first to reveal that blood-derived a beta can enter the brain, form the a beta-related pathologies and induce functional deficits of neurons. our study provides novel insight into ad pathogenesis and provides evidence that supports the development of therapies for ad by targeting a beta metabolism in both the brain and the periphery. |
| WOS关键词 | PRECURSOR PROTEIN ; SECRETASE ACTIVITY ; APOLIPOPROTEIN-E ; BRAIN-BARRIER ; PEPTIDE ; ANGIOPATHY ; CLEARANCE ; INDUCTION ; DENSITY ; TISSUES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
| WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000450892900008 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373035 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Song, W.; Wang, Y-J |
| 作者单位 | 1.Third Mil Med Univ, Daping Hosp, Dept Neurol, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China 2.Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing, Peoples R China 3.Chongqing Med Univ, Childrens Hosp, Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China 4.Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & L, Chongqing, Peoples R China 5.Third Mil Med Univ, Brain Res Ctr, Chongqing, Peoples R China 6.Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Chongqing, Peoples R China 7.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 8.Univ Chinese Acad Sci, Beijing, Peoples R China 9.Univ S Florida, Morsani Coll Med, Dept Psychiat & Behav Neurosci, Neuroimmunol Lab, Tampa, FL USA 10.Univ S Florida, Morsani Coll Med, Dept Psychiat & Behav Neurosci, Silver Child Dev Ctr,Rashid Lab Dev Neurobiol, Tampa, FL USA |
| 推荐引用方式 GB/T 7714 | Bu, X-L,Xiang, Y.,Jin, W-S,et al. Blood-derived amyloid-beta protein induces alzheimer's disease pathologies[J]. Molecular psychiatry,2018,23(9):9. |
| APA | Bu, X-L.,Xiang, Y..,Jin, W-S.,Wang, J..,Shen, L-L.,...&Wang, Y-J.(2018).Blood-derived amyloid-beta protein induces alzheimer's disease pathologies.Molecular psychiatry,23(9),9. |
| MLA | Bu, X-L,et al."Blood-derived amyloid-beta protein induces alzheimer's disease pathologies".Molecular psychiatry 23.9(2018):9. |
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来源：大连化学物理研究所
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