Extensive characterization and differential analysis of endogenous peptides from bombyx batryticatus using mass spectrometric approach
文献类型：期刊论文
| 作者 | Bai, Yunpeng1; Zhao, Qiang1,2; He, Meixi1,2; Ye, Xueting1,2; Zhang, Xiaozhe1 |
| 刊名 | Journal of pharmaceutical and biomedical analysis
 |
| 出版日期 | 2019-01-30 |
| 卷号 | 163页码:78-87 |
| 关键词 | Peptidomics Bombyx batryticatus Cysteine tagging Differential analysis |
| ISSN号 | 0731-7085 |
| DOI | 10.1016/j.jpba.2018.09.033 |
| 通讯作者 | Zhang, xiaozhe(zhangxz@dicp.ac.cn) |
| 英文摘要 | Bombyx batryticatus, the dried larva of bombyx mori l (4th-5th instars) infected with beauveria bassiana vuill, is an important animal-derived medicine effective against several diseases. the metamorphosis of silkworm can result insignificant changes in the levels of proteins and polypeptides in the 4th and 5th instar larvae. here, we performed extensive characterization of bombyx batryticatus peptides, including polypeptides containing cysteines, using an ms-based data mining strategy. a total of 779 peptides with various ptms (post-translational modifications) were identified through database search and de novo sequencing. some of these peptides might have important biological activities. besides, the differential analysis of polypeptides between the head and body of bombyx batryticatus was performed to provide a clinical basis for rational use of the drugs derived from it. this study illustrates the abundance and sequences of endogenous bombyx batryticatus polypeptides, and thus, provides potential candidates for the screening of active compounds for future biological research and drug discovery studies. (c) 2018 elsevier b.v. all rights reserved. |
| WOS关键词 | MULTIDIMENSIONAL LIQUID-CHROMATOGRAPHY ; INHIBITORY PEPTIDES ; SILKWORM ; IDENTIFICATION ; QUANTIFICATION ; PURIFICATION ; PEPTIDOMICS ; CHEMISTRY ; HEMOLYMPH ; PROTEIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Analytical ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000451360900010 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373048 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Zhang, Xiaozhe |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Zhongshan Rd 457, Dalian 116023, Peoples R China 2.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Yunpeng,Zhao, Qiang,He, Meixi,et al. Extensive characterization and differential analysis of endogenous peptides from bombyx batryticatus using mass spectrometric approach[J]. Journal of pharmaceutical and biomedical analysis,2019,163:78-87. |
| APA | Bai, Yunpeng,Zhao, Qiang,He, Meixi,Ye, Xueting,&Zhang, Xiaozhe.(2019).Extensive characterization and differential analysis of endogenous peptides from bombyx batryticatus using mass spectrometric approach.Journal of pharmaceutical and biomedical analysis,163,78-87. |
| MLA | Bai, Yunpeng,et al."Extensive characterization and differential analysis of endogenous peptides from bombyx batryticatus using mass spectrometric approach".Journal of pharmaceutical and biomedical analysis 163(2019):78-87. |
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来源：大连化学物理研究所
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