Synthesis of benzofuran-fused 1,4-dihydropyridines via bifunctional squaramide-catalyzed formal [4+2] cycloaddition of azadienes with malononitrile
文献类型：期刊论文
| 作者 | Gu, Zheng2; Wu, Bo1; Jiang, Guo-Fang2; Zhou, Yong-Gui1 |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 36期号:12页码:1130-1134 |
| 关键词 | 1,4-dihydropyridines Cycloaddition Azadienes Tandem reactions Organocatalysis Asymmetric synthesis |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201800330 |
| 通讯作者 | Zhou, yong-gui(ygzhou@dicp.ac.cn) |
| 英文摘要 | An efficient bifunctional squaramide-catalyzed michael addition/cyclization of azadienes with malononitrile has been successfully developed, providing a facile access to chiral benzofuran-fused 1,4-dihydropyridines with excellent yields, wide substrate scope and up to 99% ee. additionally, this formal [4+2] cycloaddition can be performed in gram scale without noticeable loss of yield and enantioselectivity. |
| WOS关键词 | ORTHO-QUINONE METHIDES ; ENANTIOSELECTIVE CONJUGATE ADDITIONS ; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS ; DIELS-ALDER REACTION ; K+ CHANNEL OPENER ; IN-SITU ; ALPHA,BETA-UNSATURATED IMIDES ; KINETIC RESOLUTION ; MANNICH REACTION ; TRANSFER HYDROGENATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000450017200002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373100 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Zhou, Yong-Gui |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Liaoning, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,et al. Synthesis of benzofuran-fused 1,4-dihydropyridines via bifunctional squaramide-catalyzed formal [4+2] cycloaddition of azadienes with malononitrile[J]. Chinese journal of chemistry,2018,36(12):1130-1134. |
| APA | Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,&Zhou, Yong-Gui.(2018).Synthesis of benzofuran-fused 1,4-dihydropyridines via bifunctional squaramide-catalyzed formal [4+2] cycloaddition of azadienes with malononitrile.Chinese journal of chemistry,36(12),1130-1134. |
| MLA | Gu, Zheng,et al."Synthesis of benzofuran-fused 1,4-dihydropyridines via bifunctional squaramide-catalyzed formal [4+2] cycloaddition of azadienes with malononitrile".Chinese journal of chemistry 36.12(2018):1130-1134. |
入库方式： iSwitch采集
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。