Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins
文献类型：期刊论文
| 作者 | Bi, Changfen1,2; Zhang, Sitong3; Li, Yiliang1,2; He, Xiwen3; Chen, Langxing3,4; Zhang, Yukui3,5 |
| 刊名 | New journal of chemistry
 |
| 出版日期 | 2018-11-07 |
| 卷号 | 42期号:21页码:17331-17338 |
| ISSN号 | 1144-0546 |
| DOI | 10.1039/c8nj01711e |
| 通讯作者 | Li, yiliang() ; Chen, langxing(lxchen@nankai.edu.cn) |
| 英文摘要 | In this work, a novel strategy is developed for the fabrication of phenylboronic acid functionalized iron oxide magnetic nanoparticles (mnps) via distillation-precipitation polymerization and thiol-yne click chemistry. firstly, silica was coated on the fe3o4 mnps using a sol-gel method to obtain fe3o4@sio2. subsequently, the vinyl groups were grated onto the silica-modified fe3o4 surface using 3-methacryloyloxypropyltrimethoxysilane. next, alkynyl groups as the clickable sites were modified on the mnps to obtain the product fe3o4@ppma via distillation-precipitation polymerization of the vinyl end groups with propargyl methacrylate, ethylene glycol dimethacrylate. finally, phenylboronic acid was grafted on the surface of fe3o4@ppma via thiol-yne click chemistry. the morphology, structure, and composition of all the synthesized phenylboronic acid functionalized fe3o4 mnps (fe3o4@ppma-mpba) were characterized by transmission electron microscopy (tem), fourier transform infrared (ft-ir) spectroscopy, x-ray powder diffraction (xrd), vibrating sample magnetometry (vsm), x-ray photoelectron spectroscopy (xps) and thermogravimetric analysis (tga). three glycoproteins ovalbumin, transferrin, and horseradish peroxidase and two non-glycoproteins lysozyme and horse heart cytochrome are the chosen target proteins and their adsorption performance on fe3o4@ppma-mpba is investigated. the fe3o4@ppma-mpba mnps exhibited outstanding advantages towards glycoproteins including high adsorption capacity, excellent specificity, repeatability and good enrichment recovery. furthermore, the fe3o4@ppma-mpba mnps could efficiently enrich glycoproteins from real egg white samples. this study provides a feasible strategy for the surface functionalization of boronate affinity nanomaterials for the selective isolation and enrichment of glycoproteins. |
| WOS关键词 | TRANSFER RADICAL POLYMERIZATION ; SELECTIVE ENRICHMENT ; TRACE GLYCOPROTEINS ; EFFICIENT APPROACH ; GLYCOSYLATION ; CANCER ; RECOGNITION ; METASTASIS ; COMPOSITES ; CAPTURE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000448568100017 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2373143 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Li, Yiliang; Chen, Langxing |
| 作者单位 | 1.Peking Union Med Coll, Inst Radiat Med, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China 2.Chinese Acad Med Sci, Tianjin 300192, Peoples R China 3.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Res Ctr Analyt Sci,Coll Chem, Tianjin 300071, Peoples R China 4.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bi, Changfen,Zhang, Sitong,Li, Yiliang,et al. Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins[J]. New journal of chemistry,2018,42(21):17331-17338. |
| APA | Bi, Changfen,Zhang, Sitong,Li, Yiliang,He, Xiwen,Chen, Langxing,&Zhang, Yukui.(2018).Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins.New journal of chemistry,42(21),17331-17338. |
| MLA | Bi, Changfen,et al."Boronic acid-functionalized iron oxide magnetic nanoparticles via distillation-precipitation polymerization and thiol-yne click chemistry for the enrichment of glycoproteins".New journal of chemistry 42.21(2018):17331-17338. |
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来源：大连化学物理研究所
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