中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Nkg2a is a nk cell exhaustion checkpoint for hcv persistence

文献类型:期刊论文

作者Zhang, Chao1,2,3; Wang, Xiao-mei4; Li, Shu-ran1,2,3,5; Twelkmeyer, Trix1,2,6; Wang, Wei-hong1,2,3,5; Zhang, Sheng-Yuan1,2,3,7; Wang, Shu-feng8; Chen, Ji-zheng9,10; Jin, Xia6; Wu, Yu-zhang8
刊名Nature communications
出版日期2019-04-03
卷号10页码:11
ISSN号2041-1723
DOI10.1038/s41467-019-09212-y
通讯作者Chen, hai-rong(hairong.chen@ibp.ac.cn) ; Tang, hong(htang@ips.ac.cn)
英文摘要Exhaustion of cytotoxic effector natural killer (nk) and cd8(+) t cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis c virus (hcv) infection remains poorly defined. here we show, using the humanized c/o-tg mice permissive for persistent hcv infection, that nk and cd8(+) t cells become sequentially exhausted shortly after their transient hepatic infiltration and activation in acute hcv infection. hcv infection upregulates qa-1 expression in hepatocytes, which ligates nkg2a to induce nk cell exhaustion. antibodies targeting nkg2a or qa-1 prevents nk exhaustion and promotes nk-dependent hcv clearance. moreover, reactivated nk cells provide sufficient ifn-gamma that helps rejuvenate polyclonal hcv cd8(+) t cell response and clearance of hcv. our data thus show that nkg2a serves as a critical checkpoint for hcv-induced nk exhaustion, and that nkg2a blockade sequentially boosts interdependent nk and cd8(+) t cell functions to prevent persistent hcv infection.
WOS关键词HEPATITIS-C VIRUS ; NATURAL-KILLER-CELLS ; T-CELLS ; UP-REGULATION ; IN-VITRO ; INFECTION ; RESPONSES ; ACTIVATION ; BLOCKADE ; EXPRESSION
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000463170600006
URI标识http://www.irgrid.ac.cn/handle/1471x/2373162
专题武汉病毒研究所
通讯作者Chen, Hai-rong; Tang, Hong
作者单位1.Chinese Acad Sci, Joint Lab Infect & Immun, Inst Pasteur Shanghai, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China
4.Jilin Univ, Dept Hepatol, Hosp 1, Changchun 130021, Jilin, Peoples R China
5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Pasteur Shanghai, Key Lab Mol Virol & Immunol, Shanghai 200031, Peoples R China
7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
8.Third Mil Med Univ, Inst Immunol, Chongqing 400038, Peoples R China
9.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
10.Chinese Acad Sci, Wuhan Inst Virol, Ctr Viral Pathol, Wuhan 430071, Hubei, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chao,Wang, Xiao-mei,Li, Shu-ran,et al. Nkg2a is a nk cell exhaustion checkpoint for hcv persistence[J]. Nature communications,2019,10:11.
APA Zhang, Chao.,Wang, Xiao-mei.,Li, Shu-ran.,Twelkmeyer, Trix.,Wang, Wei-hong.,...&Tang, Hong.(2019).Nkg2a is a nk cell exhaustion checkpoint for hcv persistence.Nature communications,10,11.
MLA Zhang, Chao,et al."Nkg2a is a nk cell exhaustion checkpoint for hcv persistence".Nature communications 10(2019):11.

入库方式: iSwitch采集

来源:武汉病毒研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。